AM-Imidazole-PA-Boc

Product Name: AM-Imidazole-PA-Boc
CAS No.: 2357108-99-5
Chemical Name: AM-Imidazole-PA-Boc
Synonyms: AM-Imidazole-PA-Boc;tert-butyl (3-(4-(aminomethyl)-1H-imidazol-1-yl)propyl)carbamate;Carbamic acid, N-[3-[4-(aminomethyl)-1H-imidazol-1-yl]propyl]-, 1,1-dimethylethyl ester
CBNumber: CB38054655
Molecular Formula: C12H22N4O2
Formula Weight: 254.33
MOL File: 2357108-99-5.mol

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AM-Imidazole-PA-Boc Property

Boiling point:: 463.0±30.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
form: Oil
pka: 12.75±0.46(Predicted)
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

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AM-Imidazole-PA-Boc Chemical Properties,Usage,Production

Biological Activity

AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 [1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

AM-Imidazole-PA-Boc Preparation Products And Raw materials

Raw materials

Preparation Products

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AM-Imidazole-PA-Boc Suppliers

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2357108-99-5, AM-Imidazole-PA-BocRelated Search:

AM-Imidazole-PA-Boc

Carbamic acid, N-[3-[4-(aminomethyl)-1H-imidazol-1-yl]propyl]-, 1,1-dimethylethyl ester

tert-butyl (3-(4-(aminomethyl)-1H-imidazol-1-yl)propyl)carbamate

2357108-99-5