Zotatifin

Product Name: Zotatifin
CAS No.: 2098191-53-6
Chemical Name: Zotatifin
Synonyms: Zotatifin;Zotatifin (Synonyms: eFT226);4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile;Benzonitrile, 4-[(5aR,6S,7S,8R,8aS)-7-[(dimethylamino)methyl]-6,7,8,8a-tetrahydro-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl]-
CBNumber: CB38067114
Molecular Formula: C28H29N3O5
Formula Weight: 487.55
MOL File: 2098191-53-6.mol

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Zotatifin Property

Boiling point:: 622.4±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
pka: 10.10±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: QYCXWOACFWMQFO-WZWZCULESA-N
SMILES: C(#N)C1=CC=C([C@]23[C@H](C4=CC=CC=C4)[C@@H](CN(C)C)[C@@H](O)[C@@]2(O)C2=C(O3)C=C(OC)N=C2OC)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0043584
Product name: Zotatifin
Purity: 99.58%
Packaging: 1mg
Price: $1350
Updated: 2021/12/16

ChemScene

Product number: CS-0043584
Product name: Zotatifin
Purity: 99.58%
Packaging: 2mg
Price: $2500
Updated: 2021/12/16

ChemScene

Product number: CS-0043584
Product name: Zotatifin
Purity: 99.58%
Packaging: 5mg
Price: $3800
Updated: 2021/12/16

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Zotatifin Chemical Properties,Usage,Production

Uses

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM)[2]. Zotatifin induces cell apoptosis[1].

in vivo

Zotatifin (intravenous injection; 1 mg/kg; 14-22 days) decreases tumor volume, inhibits the TMD8 xenograft-bearing, HBL1 xenograft-bearing, Pfeiffer xenograft-bearing, SU-DHL-6 xenograft-bearing, SU-DHL-10 xenograft-bearing and Ramos-bearing animals’tumor growth as percentage of 97%, 87%, 70%, 83%, 37% and 75%, respectively^[1].Zotatifin (intravenous injection; 0.001 mg/kg-1 mg/kg; 15 days) inhibits the growth of B-cell lymphoma xenografts and is well-tolerated against B-cell lymphoma xenograft models in vivo^[1].

Animal Model:	B-cell lymphoma xenograft model^[1]
Dosage:	0.001 mg/kg; 0.1 mg/kg; 1 mg/kg
Administration:	Intravenous injection; 15 days
Result:	Showed efficacy in B-cell lymphoma xenograft models.

IC 50

eIF4

References

[1] Peggy A. Thompson, et al. Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-tumor Activity in B-cell Malignancies.
[2] Gordon DE, et al. ASARS-CoV-2proteininteractionmaprevealstargetsfordrugrepurposing.Nature.2020 Apr 30. DOI:10.1038/s41586-020-2286-9

Zotatifin Preparation Products And Raw materials

Raw materials

Preparation Products

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Zotatifin Suppliers

China 32 United States 2 Global 34

Chengdu PEIP Pharmaceutical Technology Co., LTD.

Tel: 028-61715638 18011352545
Fax: QQ：1242335375
Email: 1242335275@qq.com
Country: China
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Guangzhou Younan Technology Co., Ltd

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Fax: QQ：3283937693
Email: YN_research@163.com
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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Email: 15151849396@163.com
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ShangHai ChuanQian Chemcial Technique Centre

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Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9856
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2098191-53-6, ZotatifinRelated Search:

Zotatifin

Zotatifin (Synonyms: eFT226)

4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile

Benzonitrile, 4-[(5aR,6S,7S,8R,8aS)-7-[(dimethylamino)methyl]-6,7,8,8a-tetrahydro-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl]-

2098191-53-6