ASN007

Product Name: ASN007
CAS No.: 2055597-12-9
Chemical Name: ASN007
Synonyms: ASN007;ERK-IN-3;ASN007 free base;ASN007（ERAS 007）;ERK-IN-3, 10 mM in DMSO;ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide;(S)-N-(2-Amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-
CBNumber: CB38080025
Molecular Formula: C22H25ClFN7O2
Formula Weight: 473.93
MOL File: 2055597-12-9.mol

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ASN007 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (527.50 mM; Need ultrasonic)
form: Solid
pka: 12.73±0.46(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 100mg
Price: $1550
Updated: 2021/12/16

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ASN007 Chemical Properties,Usage,Production

Biological Activity

ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations[1]. ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].

References

[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

ASN007 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASN007 Suppliers

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2055597-12-9, ASN007Related Search:

ASN007

ASN007 free base

N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide

ERK-IN-3

ASN007（ERAS 007）

ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3

1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-

N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide

(S)-N-(2-Amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1H-imidazole-4-carboxamide

ERK-IN-3, 10 mM in DMSO

2055597-12-9