ChemicalBook > CAS DataBase List > Pirtobrutinib
Pirtobrutinib
- Product Name
- Pirtobrutinib
- CAS No.
- 2101700-15-4
- Chemical Name
- Pirtobrutinib
- Synonyms
- Pirtobrutinib;Pirtobrutinib (LOXO-305);loxo-305;LY 3527727;BTK inhibitor 16;Florfenicol Impurity 16;LOXO-305，LY 3527727，Pirtobrutinib;(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-;LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation
- CBNumber
- CB38153637
- Molecular Formula
- C22H21F4N5O3
- Formula Weight
- 479.43
- MOL File
- 2101700-15-4.mol
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Pirtobrutinib Property
- Boiling point:
- 619.2±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, stored under nitrogen
- solubility
- DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
- form
- A solid
- pka
- 13.32±0.46(Predicted)
- color
- White to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
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Pirtobrutinib Chemical Properties,Usage,Production
Description
Pirtobrutinib, or LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover.
Pirtobrutinib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pirtobrutinib manufacturers
Shanghai Joiny Pharmaceutical Co.,LTD
- Product
- Pirtobrutinib 2101700-15-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2024-01-08