Piperonal Related Compound 1

Product Name: Piperonal Related Compound 1
CAS No.: 88755-39-9
Chemical Name: Piperonal Related Compound 1
Synonyms: TadalafilImpurity88;Piperonal Impurity 1;Piperonal Related Compound 1;RUNX1/ETO tetramerization-IN-1;1,3-Benzodioxole-5-butanoic acid, α-1,3-benzodioxol-5-yl-γ-oxo-
CBNumber: CB38176427
Molecular Formula: C18H14O7
Formula Weight: 342.3
MOL File: 88755-39-9.mol

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Piperonal Related Compound 1 Property

Boiling point:: 598.6±50.0 °C(Predicted)
Density: 1.472±0.06 g/cm3(Predicted)
pka: 4.04±0.23(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Piperonal Related Compound 1 Chemical Properties,Usage,Production

Uses

RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO (EC50=0.25 μM), restores gene expression down-regulated by RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO-depending SKNO-1 cells, and reduces the RUNX1/ETO-related tumor growth in a mouse model[1][2][3].

in vivo

RUNX1/ETO tetramerization-IN-1 (compound 7.44) (200-250 μg/kg; i.p.; 5 times per week; 130 d) delays tumor growth of RUNX1/ETO cells in mice^[2].

Animal Model:	NSG immunodeficient mice (NOD.Cg-Prkdc^scid Il2rg^tm1WjI/SzJ) injected with Kasumi-1 cells^[2]
Dosage:	200-250 μg/Kg
Administration:	Intraperitoneal injection; 5 times per week, for 130 days
Result:	Reduced the dissemination of leukemic cells, remained 75% mice alive at day 130 post-treatment.

References

[1] Metz A, et al. From determinants of RUNX1/ETO tetramerization to small-molecule protein-protein interaction inhibitors targeting acute myeloid leukemia. J Chem Inf Model. 2013 Sep 23;53(9):2197-202. DOI:10.1021/ci400332e
[2] Schanda J, et al. Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization. Haematologica. 2017 May;102(5):e170-e174. DOI:10.3324/haematol.2016.161570
[3] Gopalswamy M, et al. Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects. Sci Rep. 2022 Aug 19;12(1):14158. DOI:10.1038/s41598-022-17913-6
[4] Kaoud TS, et al. From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Med Chem Lett. 2012 Aug 6;3(9):721-725. DOI:10.1021/ml300129b

Piperonal Related Compound 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperonal Related Compound 1 Suppliers

China 7 United States 1 Global 8

Shenzhen Botel Biotechnology Co. Ltd.

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TargetMol Chemicals Inc.

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88755-39-9, Piperonal Related Compound 1Related Search:

PIPERONYL FORMALDEHYDE

Piperonal Related Compound 1

Piperonal Impurity 1

1,3-Benzodioxole-5-butanoic acid, α-1,3-benzodioxol-5-yl-γ-oxo-

TadalafilImpurity88

RUNX1/ETO tetramerization-IN-1

88755-39-9