ChemicalBook > CAS DataBase List > 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL

1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL

Product Name
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
CAS No.
210580-75-9
Chemical Name
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
Synonyms
AL-34662;AL 34497;1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL;1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-
CBNumber
CB3822775
Molecular Formula
C10H13N3O
Formula Weight
191.23
MOL File
210580-75-9.mol
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1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Property

Melting point:
170-172 °C(Solv: dichloromethane (75-09-2))
Boiling point:
372.8±22.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
crystalline solid
pka
9.30±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10011546
Product name
AL 34662
Purity
≥98%
Packaging
1mg
Price
$13
Updated
2023/06/20
Cayman Chemical
Product number
10011546
Product name
AL 34662
Purity
≥98%
Packaging
5mg
Price
$51
Updated
2023/06/20
Cayman Chemical
Product number
10011546
Product name
AL 34662
Purity
≥98%
Packaging
10mg
Price
$87
Updated
2023/06/20
Cayman Chemical
Product number
10011546
Product name
AL 34662
Purity
≥98%
Packaging
50mg
Price
$376
Updated
2023/06/20
ApexBio Technology
Product number
C5271
Product name
AL34662
Packaging
50mg
Price
$437
Updated
2021/12/16
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1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Chemical Properties,Usage,Production

Biological Activity

al 34662 is a potent 5-ht2 receptor agonist.serotonin (5-hydroxytryptamine; 5-ht) is a major neurotransmitter in the central nervous system (cns) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs.

in vitro

al-34662 exhibited a high affinity for the rat and human 5-ht2 receptor and for cloned human 5-ht2a-c receptors. al-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. al-34662 also mobilized intracellular ca2+ in h-cm and h-tm cells, being a full agonist like 5-ht itself. al-34662's effects in the h-cm cells were potently antagonized by 5-ht2a-antagonist m-100907, but weakly by 5-ht2b-antagonist, 5-ht2b/c- antagonist and 5-ht2c antagonist. moreover, it was found that the (r)-enantiomer (al-34707) and the racemate (al-34497) were less potent and/or efficacious than al-34662 in all of these assays [1].

in vivo

al-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. it efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1].

IC 50

0.8-1.5 nm for rat and human 5-ht2 receptor

References

[1] sharif na, mclaughlin ma, kelly cr. al-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. j ocul pharmacol ther. 2007 feb;23(1):1-13.

1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Suppliers

Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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TargetMol Chemicals Inc.
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marketing@targetmol.com
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United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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MedBioPharmaceutical Technology Inc
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order@med-bio.cn
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TargetMol Chemicals Inc.
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Suzhou Zhixin Biotechnology Co., Ltd.
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Shanghai Yifei Biotechnology Co. , Ltd.
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ApexBio Technology
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United States
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210580-75-9, 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OLRelated Search:


  • AL 34497
  • AL-34662
  • 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
  • 1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-
  • 210580-75-9