TAK-653

Product Name: TAK-653
CAS No.: 1358751-06-0
Chemical Name: TAK-653
Synonyms: TAK-653;Osavampator;NBI-1065845);Osavampator(TAK-653;9-[4-(cyclohexyloxy)phenyl]-7-methyl-3H,4H-2λ?-pyrazino[2,1-c][1,2,4]thiadiazine-2,2-dione;9-(4-(Cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide;Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide
CBNumber: CB38244135
Molecular Formula: C19H23N3O3S
Formula Weight: 373.47
MOL File: 1358751-06-0.mol

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TAK-653 Property

Boiling point:: 540.8±52.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Slightly soluble: 0.1-1 mg/ml
pka: 1.71±0.40(Predicted)
form: Solid
color: White to yellow
InChI: InChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
InChIKey: PXJBHEHFVQVDDS-UHFFFAOYSA-N
SMILES: S1(=O)(=O)CCN2C=C(C)N=C(C3=CC=C(OC4CCCCC4)C=C3)C2=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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TAK-653 Chemical Properties,Usage,Production

Uses

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].

Biological Functions

TAK-653 is a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models.

in vivo

Osavampator (0.03-0.3 mg/kg, p.o., single dose) enhances visual learning and memory in normal rats^[2].
Osavampator (0.3 mg/kg, p.o., single dose) enhances sustained attention in the poor performing rats^[2].
Osavampator (0.06 mg/kg, p.o., single dose) improves working memory in monkeys^[2].
Osavampator (1 mg/kg, p.o., single dose) produces antidepressant-like effects in the rat RSBM (reduction of submissive behavior model)^[1].

Animal Model:	Normal rats^[2]
Dosage:	0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Improved the novelty discrimination index (NDI).

Animal Model:	Poor performing rats^[2]
Dosage:	0.3 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Increased correct responses and decreased omissions in the poor performing rats.

Animal Model:	Fasted monkey^[2]
Dosage:	0.06 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Significantly increased delayed match-to-sample (DMTS) accuracy at a 16-s delay interval. Maintained the beneficial effect 24 h after administration.

Animal Model:	submissive behavior model ^[1]
Dosage:	0.1 mg/kg, 1 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Led to a significant reduction in dominance levels compared with vehicle treatment starting from the seventh day of treatment and maintained throughout the study period. Had a significant effect in reducing dominance levels at 0.1 and 1 mg/kg.

IC 50

5-LO

References

[1] Hara H, et al. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats [J]. Pharmacology Biochemistry and Behavior, 2021, 211: 173289. DOI:10.1016/j.pbb.2021.173289
[2] Suzuki A, et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement [J]. Scientific Reports, 2021, 11(1): 14532. DOI:10.1038/s41598-021-93888-0

TAK-653 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAK-653 Suppliers

China 47 United States 1 Global 48

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Zhejiang J&C Biological Technology Co.,Limited

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View Lastest Price from TAK-653 manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: TAK-653 1358751-06-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2026-02-28

Shaanxi Dideu Medichem Co. Ltd

Product: TAK-653 1358751-06-0
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-12

Xi an Biohorlden Industry Trade Co Ltd

Product: TAK-653 1358751-06-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 200g
Release date: 2025-04-17

1358751-06-0, TAK-653Related Search:

Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide

TAK-653

Osavampator

9-(4-(Cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide

9-[4-(cyclohexyloxy)phenyl]-7-methyl-3H,4H-2λ?-pyrazino[2,1-c][1,2,4]thiadiazine-2,2-dione

NBI-1065845)

Osavampator(TAK-653

1358751-06-0