2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE

Product Name: 2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE
CAS No.: 241164-09-0
Chemical Name: 2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE
Synonyms: 2-Chloro-4-methyl-6-(trifluoromethyl);2-Chloro-6-methyl-4-(trifluoromethyl)pyrimidine;2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE;Pyrimidine, 2-chloro-4-methyl-6-(trifluoromethyl)-
CBNumber: CB3825251
Molecular Formula: C6H4ClF3N2
Formula Weight: 196.56
MOL File: Mol file

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2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE Property

Boiling point:: 216.5±35.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.26±0.30(Predicted)
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C587755
Product name: 2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine
Packaging: 50mg
Price: $475
Updated: 2021/12/16

TRC

Product number: C587755
Product name: 2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine
Packaging: 100mg
Price: $670
Updated: 2021/12/16

TRC

Product number: C587755
Product name: 2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 119353
Product name: 2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine
Purity: 95+%
Packaging: 100mg
Price: $428
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35407
Product name: 2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine
Purity: 95+%
Packaging: 1000mg
Price: $1250
Updated: 2021/12/16

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2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

91606-60-9

241164-09-0

Step 2: Synthesis of 2-chloro-4-methyl-6-(trifluoromethyl)pyrimidine To 4-methyl-6-(trifluoromethyl)pyrimidin-2(1H)-one (1 eq.) was added phosphorus oxychloride (POCl3, 5 eq.). The reaction mixture was stirred under reflux conditions overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently quenched with ice water and neutralized with saturated sodium hydroxide (NaOH) solution at 0 °C. After extraction with ethyl acetate (EtOAc), the organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The crude product was purified by column chromatography (eluent ratio: ethyl acetate:hexane = 1:4) to afford the target compound 2-chloro-4-methyl-6-(trifluoromethyl)pyrimidine. Example 26: 2-chloro-4-methyl-6-(trifluoromethyl)pyrimidine was prepared according to the synthesis of Example 25, using 4-methyl-6-(trifluoromethyl)pyrimidin-2-ol as starting material, to obtain 2-chloro-4-methyl-6-(trifluoromethyl)pyrimidine as a brown oily material in 37% yield. The compound showed no ionization signal in LC-MS analysis.1H NMR (CDCl3) data were as follows: δ 7.44 (s, 1H), 2.68 (s, 3H).

References

[1] Patent: WO2006/71875, 2006, A1. Location in patent: Page/Page column 89

2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE Suppliers

China 44 France 1 India 1 United States 6 Global 52

Pure Chemistry Scientific Inc.

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241164-09-0, 2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINERelated Search:

TRANS-3-(TRIFLUOROMETHYL)CINNAMOYL CHLORIDE CHLOROMETHYL TRIFLUOROMETHYL SULFIDE

2-CHLORO-4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDINE

2-Chloro-6-methyl-4-(trifluoromethyl)pyrimidine

2-Chloro-4-methyl-6-(trifluoromethyl)

Pyrimidine, 2-chloro-4-methyl-6-(trifluoromethyl)-

241164-09-0

Fluorine series