5-Benzyloxytryptophan Property

Melting point:

275-276 °C (decomp)

Boiling point:

563.4±50.0 °C(Predicted)

Density 

1.323±0.06 g/cm3(Predicted)

pka

2.22±0.10(Predicted)

form 

powder to crystal

color 

White to Light yellow to Light red

Safety

HS Code 

2922.49.4950

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

5-Benzyloxytryptophan Chemical Properties,Usage,Production

Manufacturing Process

Preparation of 5-Benzyloxytryptophan: 11 grams α-acetylamino-β-(5- benzyloxy-indolyl-3)-propionic acid was suspended in a solution of 12 grams sodium hydroxide in 90 ml water and refluxed for 24 hours. Charcoal was added to the resultant solution and the mixture filtered hot. 150 ml 2N hydrochloric acid was added to the filtrate at 70°C and 5-benzyloxytryptophan crystallized on cooling. After washing with water and drying in vacuo over silica gel, the amino acid (6.9 grams, 71%) had MP (sealed evacuated tube) 232°C, with softening, finally melting at 237° to 238°C (decomposition). Charcoal was added to the filtrate, which was filtered hot and adjusted to pH 2. On cooling a second crop of 5-benzyloxytryptophan was obtained (2.2 grams, 23%), MP (sealed evacuated tube) 230°C, with softening, finally melting at 233° to 237°C (decomposition). The overall yield of 5- benzyloxytryptophan was 9.1 grams (94%).