GGTI-286

Product Name: GGTI-286
CAS No.: 171744-11-9
Chemical Name: GGTI-286
Synonyms: GGTI-286;GGTI-286 (GGTI286);N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA;L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
CBNumber: CB3836589
Molecular Formula: C23H31N3O3S
Formula Weight: 429.58
MOL File: Mol file

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GGTI-286 Property

Boiling point:: 626.9±55.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 9.81±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 345878
Product name: GGTI-286 - CAS 171744-11-9 - Calbiochem
Purity: A potent, cell-permeable, and selective inhibitor of GGTase I.
Packaging: 250μG
Price: $209
Updated: 2023/06/20

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GGTI-286 Chemical Properties,Usage,Production

Biological Activity

GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 . GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1].

References

[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540.

GGTI-286 Preparation Products And Raw materials

Raw materials

Preparation Products

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GGTI-286 Suppliers

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171744-11-9, GGTI-286Related Search:

GGTI-286

N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA

GGTI-286 (GGTI286)

L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester

171744-11-9