GGTI-286
- Product Name
- GGTI-286
- CAS No.
- 171744-11-9
- Chemical Name
- GGTI-286
- Synonyms
- GGTI-286;GGTI-286 (GGTI286);N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA;L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
- CBNumber
- CB3836589
- Molecular Formula
- C23H31N3O3S
- Formula Weight
- 429.58
- MOL File
- Mol file
GGTI-286 Property
- Boiling point:
- 626.9±55.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 9.81±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 345878
- Product name
- GGTI-286 - CAS 171744-11-9 - Calbiochem
- Purity
- A potent, cell-permeable, and selective inhibitor of GGTase I.
- Packaging
- 250μG
- Price
- $209
- Updated
- 2023/06/20
GGTI-286 Chemical Properties,Usage,Production
Biological Activity
GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 . GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1].
References
[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540.
GGTI-286 Preparation Products And Raw materials
Raw materials
Preparation Products
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