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Dexmedetomidine hydrochloride

Product Name
Dexmedetomidine hydrochloride
CAS No.
145108-58-3
Chemical Name
Dexmedetomidine hydrochloride
Synonyms
DEXMEDETOMIDINE HCL;Dexmedetomidine Hydrochloride Injection;Precedex;4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride;4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride;5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride;4-(S)-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1 H-IMIDAZOLE MONOHY DROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE);CS-1397;DEMEDETOMIDINE HCL;Dexmedetomidine hydr
CBNumber
CB3838381
Molecular Formula
C13H17ClN2
Formula Weight
236.74
MOL File
145108-58-3.mol
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Dexmedetomidine hydrochloride Property

Melting point:
156.5-157.5°
alpha 
+52.4° (c = 1 in water)
Density 
1.17 g/cm3
storage temp. 
2-8°C
solubility 
H2O: soluble20mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D +48 to +58°, c = 1 in H2O
Merck 
14,2946
Stability:
Hygroscopic
InChI
InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/s3
InChIKey
VPNGEIHDPSLNMU-MERQFXBCSA-N
SMILES
[C@@H](C1NC=NC=1)(C1C=CC=C(C)C=1C)C.Cl |&1:0,r|
CAS DataBase Reference
145108-58-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
NI5156750
HS Code 
2933290000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0956
Product name
Dexmedetomidine hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2701
Product name
Dexmedetomidine Hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$267
Updated
2024/03/01
Sigma-Aldrich
Product number
1179333
Product name
Dexmedetomidine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
D5062
Product name
Dexmedetomidine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
20mg
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
D5062
Product name
Dexmedetomidine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$206
Updated
2024/03/01
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Dexmedetomidine hydrochloride Chemical Properties,Usage,Production

Description

Dexmedetomidine was launched in the US as an i.v. infusion for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care unit, This imidazole derivative is the (S)-enantiomer of medetomidine that can be obtained via fractional crystallization of the tartrate salt of the racemic mixture. Dexmedetomidine is a full agonist of α2 adrenoceptors with 1300-fold selectivity versus α1 compared to the less selective partial α2 agonist clonidine, a veterinary hypnotic. Dexmedetomidine is unique compared with currently available sedatives in that it provides sedation, analgesia and anxiolysis with the ability of patients to be easily awakened. Besides, it causes minimal respiratory depression unlike other available drugs such as benzodiazepines or opioids. Pharmacological studies in transgenic mice showed that the sedative, anesthetic and analgesic effects of dexmedetomidine are specifically due to the stimulation of the a2A subtype receptor. Like other α2 adrenoceptor agonists, dexmedetomidine can provoke hypotension and bradycardia probably because of its non-selective action on peripheral a2B subtype receptors in vascular smooth muscle. Dexmedetomidine is extensively metabolized into methyl and glucuronide conjugates which are mainly eliminated by renal excretion. It was found to be a CYP2D6 inhibitor but less potent than the clinically relevant standard quinidine.

Physical properties

Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1.

Originator

Orion (Finland)

Uses

Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.

Uses

highly selective, potent α2-adrenoceptor agonist, analgesic, anxiolytic, bradycardic, hypotensive, sedative, hypothermic

Definition

ChEBI: Dexmedetomidine hydrochloride is a medetomidine hydrochloride. It has a role as a sedative. It contains a dexmedetomidine. It is an enantiomer of a levomedetomidine hydrochloride.

brand name

Precedex

benefits

The chemical name of dexmedetomidine hydrochloride is (S) -4- [1- (2,3- 3,5-dimethylphenyl) ethyl] -1H- imidazole hydrochlorides. Dexmedetomidine hydrochloride has an anti-sympathetic town. The effect of quiet and analgesic, compared with U.S. support pyrimidine, with higher selectivity and a short half-life, can be clinically used for Intensive Care Therapy. Start intubation and calmness using a lung ventilator patient during treatment. Meanwhile, the medicine can also reduce narcotic consumption, improve hand incidence of hemodynamic stability, and reduce myocardial ischaemia in art.

Biological Activity

Active isomer of Medetomide (4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride ), a potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Biochem/physiol Actions

Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.

Side effects

Dexmedetomidine hydrochloride may cause serious side effects including: low or high blood pressure,slow heart rate, and abnormal heart rate.

Synthesis

In a 500mL round-bottomed flask, (S)-1 (18.6g, 93mmo1) is dissolved into 50mL dehydrated alcohol, and adding HC1/ ethanolic soln to adjust pH is 2～3, add THF solution 300mL, placement is spent the night, and now adularescent crystallization, filters, crude product is through ethyl acetate/ethyl alcohol recrystallization, filter, infrared drying oven is dried to obtain dexmedetomidine hydrochloride (20.1g, yield 91.5%).

storage

-20°C

Dexmedetomidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dexmedetomidine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dexmedetomidine hydrochloride 145108-58-3
Price
US $0.00/g/Bag
Min. Order
1g
Purity
98%-102%; USP
Supply Ability
1000G
Release date
2021-07-08
Jinan Million Pharmaceutical Co., Ltd
Product
Dexmedetomidine hydrochloride 145108-58-3
Price
US $6.00/kg
Min. Order
0.1kg
Purity
99.71
Supply Ability
60 tons
Release date
2024-09-28
CONTIDE BIOTECH CO.,LTD
Product
Dexmedetomidine hydrochloride 145108-58-3
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-03-25

145108-58-3, Dexmedetomidine hydrochlorideRelated Search:

Medetomidine HCl Propofol Ferric sulfate Tetracaine hydrochloride Donepezil Hydrochloride Butenafine hydrochloride Donepezil Levamisole hydrochloride Levocetirizine dihydrochloride Dexmedetomidine Dexmedetomidine-021 Medetomidine Impurity 14 DEXTROMETHORPHAN N-OXIDE 2,3-Dimethylbenzoic acid DexMedetoMidine IMpurity Medetomidine Impurity 3 Medetomidine Impurity 34 Dexmedetomidine Impurity 19 HCl

  • 4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride
  • 4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride
  • DEXMEDETOMIDINE HCL
  • DEXMEDETOMIDINE HYDROCHLORIDE
  • DEMEDETOMIDINE HCL
  • Dexmedetomidine(Pilot)
  • 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride
  • 4-((S)-α,2,3-Trimethylbenzyl)imidazole monohydrochloride
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  • (S)-4-(1-(2,3-diMethylphenyl)ethyl)-1H-iMidazole hydrochloride
  • 1H-IMidazole,5-[(1S)-1-(2,3-diMethylphenyl)ethyl]-, hydrochloride (1:1)
  • 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole,hydrochloride (1:1)
  • Dexmedetomidine hydrochloride 4-((S)-alpha,2,3-Trimethylbenzyl)imidazole monohydrochloride
  • (S)-Medetomidine hydrochloride
  • 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
  • Given dexmedetomidine hydrochloride
  • Dexmedetomidine Hydrochloride (200 mg)
  • Dexmedetomidine HCl (Precedex)
  • (S)-5-(1-(2,3-DiMethylphenyl)ethyl)-1H-iMidazole hydrochloride
  • Dexmedetomidine Hydrochloride Injection
  • (S)-4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole Hydrochloride salt
  • 4-(S)-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1 H-IMIDAZOLE MONOHY DROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE)
  • 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride
  • Dexmedetomidine hydrochloride, 99%, an agonist of adrenergic alpha-2 receptor
  • Dexmedetomidine HCl 99%
  • ((addition))-Medetomidine hydrochloride
  • CS-1397
  • Medetomidine Impurity 39（Dexmedetomidine HCl）
  • Precedex
  • (+)-Medetomidine Hydrochloride
  • (S)-4-(alpha,2,3-Trimethybenzyl)-1H-imidazole Hydrochloride
  • Dexmedetomidine hydrochloride USP/EP/BP
  • Dexmedetomidine hydrogensulfate salt
  • Dexmedetomidine hydr
  • Omega cinnamate methyl ester
  • Dexmedetomidine HCl [(S)-Medetomidine
  • Dexmedetomidine HydrochlorideQ: What is Dexmedetomidine Hydrochloride Q: What is the CAS Number of Dexmedetomidine Hydrochloride Q: What is the storage condition of Dexmedetomidine Hydrochloride Q: What are the applications of Dexmedetomidine Hydrochloride
  • Dexmedetomidine Hydrochloride (1179333)
  • Medetomidine Impurity 57
  • Dexmedetomidine hydrochloride hcl
  • 145108-58-3
  • Inhibitors
  • API
  • 145108-58-3