PD 166793

Product Name: PD 166793
CAS No.: 199850-67-4
Chemical Name: PD 166793
Synonyms: PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
CBNumber: CB3840520
Molecular Formula: C17H18BrNO4S
Formula Weight: 412.3
MOL File: 199850-67-4.mol

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PD 166793 Property

Melting point:: 192-193℃
Density: 1.457
storage temp.: Sealed in dry,2-8°C
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
color: White to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444284
Product name: MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem
Packaging: 5mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 23762
Product name: PD 166793
Purity: ≥98%
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 23762
Product name: PD 166793
Purity: ≥98%
Packaging: 10mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 23762
Product name: PD 166793
Purity: ≥98%
Packaging: 25mg
Price: $392
Updated: 2024/03/01

Tocris

Product number: 2520
Product name: PD166793
Purity: ≥99%(HPLC)
Packaging: 10
Price: $151
Updated: 2021/12/16

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PD 166793 Chemical Properties,Usage,Production

Uses

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

General Description

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biological Activity

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Biochem/physiol Actions

Cell permeable: yes

storage

Desiccate at +4°C

PD 166793 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 166793 Suppliers

China 44 Germany 1 Japan 1 The Netherlands 1 United Kingdom 1 United States 14 Global 62

J & K SCIENTIFIC LTD.

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199850-67-4, PD 166793Related Search:

DECABROMOBIPHENYL 2,2-diphenyl-1-picrylhydrazyl PD 166285 PD173955 PD 0325901 PD 98059 PD184352 PD318088 PD 166793

PD 166793

(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid

N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine

(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid

MMP-2/MMP-3 Inhibitor

L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-

(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci

PD 166793 USP/EP/BP

PD-166793-0000

(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid

199850-67-4

Angiogenesis and Metastasis

Protease inhibitor