PD 166793
- Product Name
- PD 166793
- CAS No.
- 199850-67-4
- Chemical Name
- PD 166793
- Synonyms
- PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
- CBNumber
- CB3840520
- Molecular Formula
- C17H18BrNO4S
- Formula Weight
- 412.3
- MOL File
- 199850-67-4.mol
PD 166793 Property
- Melting point:
- 192-193℃
- Density
- 1.457
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 444284
- Product name
- MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem
- Packaging
- 5mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 23762
- Product name
- PD 166793
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 23762
- Product name
- PD 166793
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 23762
- Product name
- PD 166793
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $392
- Updated
- 2024/03/01
- Product number
- 2520
- Product name
- PD166793
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $151
- Updated
- 2021/12/16
PD 166793 Chemical Properties,Usage,Production
Uses
PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.
General Description
A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Biological Activity
Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at +4°C
PD 166793 Preparation Products And Raw materials
Raw materials
Preparation Products
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