5-Methoxybenzofuran-3(2H)-one
- Product Name
- 5-Methoxybenzofuran-3(2H)-one
- CAS No.
- 39581-55-0
- Chemical Name
- 5-Methoxybenzofuran-3(2H)-one
- Synonyms
- AKOS BC-0911;5-METHOXY-BENZOFURAN-3-ONE;5-Nitro-3-Benzofuranone (2);5-methoxy-1-benzofuran-3-one;5-methoxybenzofuran-3(2H)-one;5-Methoxy-3(2H)-benzofuranone;3(2H)-Benzofuranone, 5-Methoxy-;5-Methoxy-1-benzofuran-3(2H)-one;1H-1,4-Diazepine,hexahydro-4-(phenylmethyl)-
- CBNumber
- CB3840863
- Molecular Formula
- C9H8O3
- Formula Weight
- 164.16
- MOL File
- 39581-55-0.mol
5-Methoxybenzofuran-3(2H)-one Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M341328
- Product name
- 5-Methoxybenzofuran-3(2H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 5188AB
- Product name
- 5-Methoxy-1-benzofuran-3(2H)-one
- Packaging
- 250mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 5188AB
- Product name
- 5-Methoxy-1-benzofuran-3(2H)-one
- Packaging
- 1g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- CHM0079552
- Product name
- 5-METHOXY-BENZOFURAN-3-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $968.97
- Updated
- 2021/12/16
- Product number
- CHM0079552
- Product name
- 5-METHOXY-BENZOFURAN-3-ONE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1445.42
- Updated
- 2021/12/16
5-Methoxybenzofuran-3(2H)-one Chemical Properties,Usage,Production
Synthesis
5-Methoxybenzofuran-3(2H)-one is synthesised using 2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethanone as raw material by chemical reaction. The specific synthesis steps are as follows:
To an ice-cooled solution of boron trichloride (1.2 equiv., 10 mmol, 10 ml of a solution of 1M BC13 in dichloromethane) under N2-atmosphere was added dropwise a solution of J (1 g, 8 mmol,) in dichloromethane (5 ml). Then, chloroacetonitrile (0.7 g, 10 mmol, 1.2 equiv. ) was added dropwise, followed by aluminum(III) chloride (0.5 g, 4 mmol, 0.5 equiv. ) in one portion. The reaction mixture was allowed to warm up to room temperature and was stirred for 6 h. The reaction mixture was diluted with dichloromethane and quenched with IN hydrochloric acid at 0°C. After stirring for 10 min, the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with brine, dried (MgS04) and concentrated Purification by flash chromatography on silica gel (eluent: dichloromethane) afforded the desired product K (1 g, yield = 60percent). Intermediate K (0.15 g, 0.75 mmol, I equiv. ) and potassium acetate (0.22 g, 2.2 mmol, 3 equiv. ) were refluxed in ethanol (10 ml) for 1 h. After cooling, the reaction mixture was filtered and concentrated. The residue was mixed with water, and acidified with IN hydrochloric acid to pH = 1. The aqueous solution was extracted with ethyl acetate, the combined extracts were dried (MgS04), filtered and concentrated to afford the desired product L (110 mg, yield = 90 percent) as a pink solid The experimental procedures for the condensation reaction of compound L with 4-nitroaniline in acetic acid to form compound M, followed by Vilsmeier-Haack formulation and subsequent Knoevenagel condensation of the benzofuran carbaldehyde N with ethyl cyanoacetate to form compound 0, and finally, intramolecular cyclisation to compound 37 were performed using analogous procedures as exemplified in example 1 for the synthesis of compound f starting from compound a. Compound 37 was obtained as a yellow powder (30 mg, purity (LC) = 80 percent).
5-Methoxybenzofuran-3(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
5-Methoxybenzofuran-3(2H)-one Suppliers
- Tel
- 025-58742998 18136843696
- sales@deweichem.cn
- Country
- China
- ProdList
- 110
- Advantage
- 58
- Tel
- 513-85982855 18921614129
- Fax
- 051385915507
- sales@xianxingpharm.com
- Country
- China
- ProdList
- 2011
- Advantage
- 61
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 921
- Advantage
- 56
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 18151128828
- Fax
- -
- hc-sales@foxmail.com
- Country
- China
- ProdList
- 2598
- Advantage
- 55
- Tel
- 18019252918
- Fax
- QQ:1454668768
- sale@amkchem.com
- Country
- China
- ProdList
- 15363
- Advantage
- 55
- Tel
- 18086626237 18086626237
- Fax
- qq:2693528373
- sales@debyesci.com
- Country
- China
- ProdList
- 2644
- Advantage
- 56
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6463
- Advantage
- 55
- Tel
- 515-88280676 18921872653
- sales@ximanbio.com
- Country
- China
- ProdList
- 1521
- Advantage
- 56
- Tel
- 18622939839
- Fax
- QQ:343281693
- tjby921@163.com
- Country
- China
- ProdList
- 510
- Advantage
- 55
- Tel
- 0519-83990708
- Fax
- 0519-83990708
- lxy2046@yeah.net
- Country
- China
- ProdList
- 476
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13320
- Advantage
- 58
- Tel
- 021-021-67759270 17717059219
- Fax
- QQ：1479352695
- sales@rlavie.com
- Country
- China
- ProdList
- 1094
- Advantage
- 55
- Tel
- 0711-3617768 13308685235
- Fax
- 0711-3616558
- lihongcai4360@sina.com
- Country
- China
- ProdList
- 1378
- Advantage
- 55
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28810
- Advantage
- 58
- Tel
- +86-（0）57185586718 +86-13336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29791
- Advantage
- 60
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15951
- Advantage
- 58
- Tel
- 13918479294
- Fax
- -
- xiebenfa@163.com
- Country
- China
- ProdList
- 3445
- Advantage
- 58
- Tel
- 13370351217 kungfu1217@1
- Fax
- QQ1400885609
- kungfu1217@163.com
- Country
- China
- ProdList
- 9010
- Advantage
- 58
- Tel
- 028-85157043 15882256948
- 676046971@qq.com
- Country
- China
- ProdList
- 4391
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34553
- Advantage
- 58
- Tel
- +86-021-67759270 +8617717059219
- Fax
- 021-67759270
- sales@rlavie.com
- Country
- China
- ProdList
- 1030
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30240
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 10058
- Advantage
- 58
- Tel
- 0519-83990708
- info@pbpharm.com
- Country
- CHINA
- ProdList
- 498
- Advantage
- 58
- Tel
- 13291169750 18151111370
- 1046215251@qq.com
- Country
- China
- ProdList
- 6723
- Advantage
- 58
- Tel
- 15705188088
- admin@jheyou.com
- Country
- CHINA
- ProdList
- 1268
- Advantage
- 58
- Tel
- 021-51698675
- jiejiegroup@126.com
- Country
- China
- ProdList
- 4273
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49374
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 021-58099077-8041 18601625411
- sales@birdotech.com
- Country
- China
- ProdList
- 9390
- Advantage
- 58
- Tel
- 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20565
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 18105366931
- creatpharm@163.com
- Country
- China
- ProdList
- 485
- Advantage
- 58
- Tel
- 19556085883
- Fax
- QQ:1494490951
- sales@machidopharma.com
- Country
- China
- ProdList
- 365
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40037
- Advantage
- 58
- Tel
- 0751-2815987 13927875076
- Fax
- 0751-2828607
- 3007432263@qq.com
- Country
- China
- ProdList
- 9970
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62163
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 0573-85609002
- zhejia01@163.com
- Country
- China
- ProdList
- 8870
- Advantage
- 58
- Tel
- 15652467323 15652467323
- sales@inno-chem.com.cn
- Country
- China
- ProdList
- 8293
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 19821570922
- angela@labgogo.com
- Country
- China
- ProdList
- 9896
- Advantage
- 58
- Tel
- 021-57520305 15221441005
- lihua@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29977
- Advantage
- 58
- Tel
- 15555063509
- 153666767@qq.com
- Country
- China
- ProdList
- 2751
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- syeu@accelachem.com
- Country
- China
- ProdList
- 11710
- Advantage
- 58
- Tel
- 18010053931
- echiral@126.com
- Country
- China
- ProdList
- 8298
- Advantage
- 58
View Lastest Price from 5-Methoxybenzofuran-3(2H)-one manufacturers
- Product
- 5-Methoxy-3-Benzofuranone 39581-55-0
- Price
- US $0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-14
- Product
- 5-METHOXY-BENZOFURAN-3-ONE 39581-55-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-25