3-BROMO-2-METHYL-BENZO[B]THIOPHENE
- Product Name
- 3-BROMO-2-METHYL-BENZO[B]THIOPHENE
- CAS No.
- 10243-15-9
- Chemical Name
- 3-BROMO-2-METHYL-BENZO[B]THIOPHENE
- Synonyms
- 3-bromo-2-methyl-benzothiophene;3-BROMO-2-METHYL-1-BENZOTHIOPHENE;3-BROMO-2-METHYL-BENZO[B]THIOPHENE;Benzo[b]thiophene, 3-bromo-2-methyl-
- CBNumber
- CB3841042
- Molecular Formula
- C9H7BrS
- Formula Weight
- 227.12
- MOL File
- 10243-15-9.mol
3-BROMO-2-METHYL-BENZO[B]THIOPHENE Property
- Melting point:
- 42-42.5 °C
- Boiling point:
- 103-104 °C(Press: 1.5 Torr)
- Density
- 1.561±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB140799
- Product name
- 3-Bromo-2-methylbenzo[b]thiophene
- Packaging
- 250mg
- Price
- $72.5
- Updated
- 2021/12/16
- Product number
- FB140799
- Product name
- 3-Bromo-2-methylbenzo[b]thiophene
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 118933
- Product name
- 3-Bromo-2-methylbenzo[b]thiophene
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FB140799
- Product name
- 3-Bromo-2-methylbenzo[b]thiophene
- Packaging
- 1g
- Price
- $218.75
- Updated
- 2021/12/16
- Product number
- Z3813
- Product name
- 3-Bromo-2-methylbenzo[b]thiophene
- Packaging
- 1g
- Price
- $243
- Updated
- 2021/12/16
3-BROMO-2-METHYL-BENZO[B]THIOPHENE Chemical Properties,Usage,Production
Synthesis
1195-14-8
10243-15-9
General procedure for the synthesis of 3-bromo-2-methyl-benzo[b]thiophene from 2-methylbenzothiophene: A solution of bromine (Br2, 2.10 mL, 6.55 g, 41.5 mmol, 1.02 eq.) in chloroform (CHCl3, 60 mL) was added slowly and dropwise over a period of 5 hr. to a solution of 2-methylbenzothiophene (5, 6.00 g, 40.8 mmol. 1.00 equiv) solution in chloroform (CHCl3, 300 mL). The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium sulfite (Na2SO3) (50 mL) and extracted with dichloromethane (CH2Cl2, 4 x 100 mL). The combined organic layers were washed with saturated aqueous sodium bicarbonate (NaHCO3) and then dried with anhydrous sodium sulfate (Na2SO4) (2 × 100 mL). The solvent was removed by distillation under reduced pressure and the product was purified by fast column chromatography (silica gel, hexane as eluent) to afford 3-bromo-2-methyl-benzo[b]thiophene (6) as a colorless solid in 96% yield (8.68 g, 38.2 mmol). Thin layer chromatography (TLC, silica gel plate, hexane as unfolding agent): rf = 0.25. 1H NMR (400 MHz, DMSO-d6): δ = 8.00-7.94 (m, 1H), 7.68-7.63 (m, 1H), 7.51-7.38 (m, 2H), 2.54 (s, 3H) ppm. 13C NMR (101 MHz. DMSO-d6): δ = 137.62, 136.57, 135.65, 125.38, 125.14, 122.75, 121.92, 105.78, 15.17 ppm. mass spectrometry (EI): m/z [M]+ of C9H7BrS Calculated value: 225.9448; measured value: 225.9446.
References
[1] Tetrahedron, 2007, vol. 63, # 38, p. 9482 - 9487
[2] Synlett, 2017, vol. 28, # 12, p. 1422 - 1426
[3] Chemistry - A European Journal, 2016, vol. 22, # 3, p. 1070 - 1075
[4] Chemistry - A European Journal, 2014, vol. 20, # 44, p. 14524 - 14530
[5] Chemistry - A European Journal, 2015, vol. 21, # 8, p. 3174 - 3177
3-BROMO-2-METHYL-BENZO[B]THIOPHENE Preparation Products And Raw materials
Raw materials
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