2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE

Product Name: 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE
CAS No.: 155-12-4
Chemical Name: 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE
Synonyms: Abemaciclib Impurity 36;2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE;2-Chloro-5-fluoro-pyrimidin-4-ol;2-Chloro-5-fluoro-4-pyrimidinone;2-Chloro-5-fluoropyriMidin-4(3H)-one;2-Chloro-5-fluoro-3H-pyriMidin-4-one;2-chloro-5-fluoro-1H-pyrimidin-6-one;2-Chloro-5-fluoro-4(3H)-pyrimidinone;2-Chloro-5-fluoro-1H-pyriMidine-6-one;2-Chloro-4-hydroxy-5-fluoropyrimidine
CBNumber: CB3842175
Molecular Formula: C4H2ClFN2O
Formula Weight: 148.52
MOL File: 155-12-4.mol

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2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE Property

Melting point:: 176-177 °C(Solv: ethanol (64-17-5))
Density: 1.70±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 4.48±0.50(Predicted)
color: White to Light yellow

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Safety

HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3381
Product name: 2-Chloro-5-fluoro-4-pyrimidinone
Purity: >98.0%(T)
Packaging: 1g
Price: $91
Updated: 2024/03/01

TCI Chemical

Product number: C3381
Product name: 2-Chloro-5-fluoro-4-pyrimidinone
Purity: >98.0%(T)
Packaging: 5g
Price: $307
Updated: 2024/03/01

TRC

Product number: C585220
Product name: 2-Chloro-5-fluoropyrimidin-4-one
Packaging: 1g
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 295630
Product name: 2-Chloro-4-hydroxy-5-fluoropyrimidine
Packaging: 10g
Price: $991
Updated: 2021/12/16

Matrix Scientific

Product number: 072662
Product name: 2-Chloro-5-fluoropyrimidin-4-one
Purity: 95+%
Packaging: 1g
Price: $43
Updated: 2021/12/16

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2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE Chemical Properties,Usage,Production

Synthesis

2927-71-1

155-12-4

The general procedure for the synthesis of 2-chloro-5-fluoropyrimidin-4(3H)-one from 2,4-dichloro-5-fluoropyrimidine was as follows: dimethylaniline (195 mL, 1.54 mol) was added to the slurry formed by 5-fluorouracil (99.73 g, 0.77 mol) and phosphoryl chloride (215 mL, 2.31 mol) under nitrogen protection, and the temperature of the reaction was maintained at 95 °C. The reaction mixture was stirred at this temperature for 3.5 hours and then cooled to room temperature and subsequently slowly poured into a stirred mixture of ice (200 g) and 6 M hydrochloric acid (200 mL). The resulting slurry was extracted with dichloromethane (2 x 400 mL), and the combined organic phases were washed with deionized water (4 x 275 mL), dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to afford 111.77 g of 5-fluoro-2,4-dichloropyrimidine (87% yield, 98.1% AUC purity as determined by HPLC) as amber oil. Next, 1.34 L of 1 M sodium hydroxide solution was slowly added to a solution of 5-fluoro-2,4-dichloropyrimidine (111.77 g, 0.67 mol) in tetrahydrofuran (377 mL) at 0 °C. The reaction mixture was stirred at room temperature for about 30 min before the pH was slowly adjusted to 6 with 1.0 M hydrochloric acid.The aqueous phase was extracted with ethyl acetate (440 mL) to remove impurities, followed by adjusting the pH to 1 with 1.0 M hydrochloric acid.The acidic aqueous phase was extracted with ethyl acetate (4 x 555 mL).The combined organic phases were washed with brine (111 mL), dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to give 2- chloro-5-fluoro-3H-pyrimidin-4-one 88.35 g (89% yield, 99% AUC purity by HPLC) as an off-white powder.

References

[1] Patent: EP1506967, 2005, A1. Location in patent: Page/Page column 67
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 18, p. 4984 - 4995
[3] Patent: US2007/66636, 2007, A1. Location in patent: Page/Page column 19; 20
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 2, p. 510 - 524
[5] Patent: US2007/60529, 2007, A1. Location in patent: Page/Page column 14

2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE Suppliers

Americas 1 China 141 Europe 2 Germany 1 India 3 Japan 1 United Kingdom 4 United States 10 Global 163

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
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Shanghai Hanhong Scientific Co.,Ltd.

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EnciPharmatech Co., Ltd

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Shanghai Ennopharm Co., Ltd.

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Hangzhou Yuhao Chemical Technology Co., Ltd

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Tianjin YongSheng Biotechnology Co., Ltd.

Tel: 022-60987737 13512258274
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Wuhan Taiyicheng Biopharmaceutical Co., Ltd.

Tel: 027-88320699
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Email: tycshyy@126.com
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View Lastest Price from 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE 155-12-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4-hydroxy-5-fluoropyrimidine 155-12-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4-hydroxy-5-fluoropyrimidine 155-12-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

155-12-4, 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONERelated Search:

4-Hydroxy-5-fluorpyrimidine 4-[(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)OXY]BENZALDEHYDE {4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]-3-METHOXYBENZYLIDENE}MALONONITRILE (2Z)-3-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]PHENYL}-2-CYANO-N-(2,4-DIMETHYLPHENYL)ACRYLAMIDE 5-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]-3-ETHOXYBENZYLIDENE}-2-THIOXODIHYDROPYRIMIDINE-4,6(1H,5H)-DIONE (2Z)-3-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]PHENYL}-2-(MORPHOLIN-4-YLCARBONYL)ACRYLONITRILE CHEMBRDG-BB 6873131 3-[(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)OXY]-4-METHOXYBENZALDEHYDE (2Z)-2-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]BENZYLIDENE}[1,3]THIAZOLO[3,2-A]BENZIMIDAZOL-3(2H)-ONE 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE

2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE

2-Chloro-4-hydroxy-5-fluoropyrimidine

2-chloro-5-fluoro-1H-pyrimidin-6-one

4(3H)-Pyrimidinone, 2-chloro-5-fluoro-

2-chloro-5-fluoro-4-hydroxypyrimidine

2-Chloro-5-fluoro-3H-pyriMidin-4-one

2-Chloro-5-fluoropyriMidin-4(3H)-one

2-Chloro-3,4-dihydro-5-fluoro-4-oxopyrimidine

2-Chloro-5-fluoro-pyrimidin-4-ol

4(1H)-Pyrimidinone, 2-chloro-5-fluoro- (9CI)

2-Chloro-5-fluoro-1H-pyriMidine-6-one

4-(1H)-Pyrimidinone, 2-chloro-5-fluoro-

2-Chloro-5-fluoro-4-pyrimidinone

2-Chloro-5-fluoropyrimidin-4(3H)-one 95+%

2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE ISO 9001：2015 REACH

2-Chloro-5-fluoro-4(3H)-pyrimidinone

N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

Abemaciclib Impurity 36

155-12-4

PYRIMIDINE