HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE
- Product Name
- HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE
- CAS No.
- 124072-89-5
- Chemical Name
- HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE
- Synonyms
- Hexahydropyridazine. 2HCl;1,2‐diazinane dihydrochloride;HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE;Hexahydripyridazine dihydrochloride;Tetrahydropyridazine dihydrochloride;Pyridazine,hexahydro-,hydrochloride(1:2);HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE ISO 9001：2015 REACH
- CBNumber
- CB3846597
- Molecular Formula
- C4H12Cl2N2
- Formula Weight
- 159.05748
- MOL File
- 124072-89-5.mol
HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE Property
- Melting point:
- 135-137℃
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C4H10N2.2ClH/c1-2-4-6-5-3-1;;/h5-6H,1-4H2;2*1H
- InChIKey
- PJUZEZLTRTTWOK-UHFFFAOYSA-N
- SMILES
- N1CCCCN1.Cl.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H294454
- Product name
- HexahydropyridazineDihydrochloride
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0038680
- Product name
- Hexahydropyridazinedihydrochloride
- Packaging
- 5g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- A108468
- Product name
- Hexahydropyridazinedihydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $6
- Updated
- 2021/12/16
- Product number
- A1352316
- Product name
- Hexahydropyridazinedihydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $6
- Updated
- 2021/12/16
- Product number
- A108468
- Product name
- Hexahydropyridazinedihydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Hexahydropyridazine Dihydrochloride is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the synthesis of completely hydrogenated dipiperidazino tetrazine, tetrazepine and tetrazone derivatives.
Synthesis
110-52-1
89990-53-4
The general procedure for the synthesis of hexahydropyridazine hydrochloride from 1,4-dibromobutane was as follows: 7.6 g of NaH (60% w/w dispersed in mineral oil, 0.19 mol, 2.2 eq.) was added to a 1-liter, three-necked, round-bottomed flask equipped with a magnetic stir bar, a dosing funnel, and nitrogen protection. NaH was washed three times with hexane, followed by the addition of 350 mL of anhydrous DMF. the reaction mixture was cooled to 0 °C via an ice bath, and then 20 g of tert-butylhydrazinium formate (0.086 mol, 1 eq.) dissolved in 50 mL of anhydrous DMF was added slowly and dropwise via the charging funnel. After the dropwise addition was completed, the reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 30 minutes. Subsequently, 10.27 mL of 1,4-dibromobutane (0.086 mol, 1 eq.) was added in a single addition at room temperature and the reaction mixture was stirred overnight. Upon completion of the reaction, the reaction was quenched with water until no gas escaped and then the mixture was partitioned between ether and water. The phases were separated and the organic phase was washed twice with water. The ether layer was concentrated under vacuum. The residue was dissolved in 300 ml of dioxane solution in 4N HCl, followed by the addition of 300 ml of diethyl ether. The mixture was stirred at room temperature for 1 hour, during which time a white solid precipitated. The white solid (13.7 g, 100% yield) was isolated by filtration and dried under vacuum. The product was characterized by 1H NMR (400 MHz, DMSO-D6) with chemical shifts δppm 1.6 (m, 4H), 3.0 (m, 4H).
References
[1] Patent: WO2006/91592, 2006, A1. Location in patent: Page/Page column 45-46
HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
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View Lastest Price from HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE manufacturers
- Product
- HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE 124072-89-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-09-26
- Product
- HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE 124072-89-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-08
- Product
- HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE 124072-89-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07