4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE

Product Name: 4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE
CAS No.: 90035-20-4
Chemical Name: 4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE
Synonyms: 4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE;Benzaldehyde, 4-[4-(trifluoromethyl)phenoxy]-
CBNumber: CB3847635
Molecular Formula: C14H9F3O2
Formula Weight: 266.22
MOL File: 90035-20-4.mol

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4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE Property

Boiling point:: 326.9±42.0 °C(Predicted)
Density: 1.297±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: W9281
Product name: 4-(4-(Trifluoromethyl)phenoxy)benzaldehyde
Packaging: 250mg
Price: $157
Updated: 2021/12/16

Ambeed

Product number: A189323
Product name: 4-(4-(Trifluoromethyl)phenoxy)benzaldehyde
Purity: 95%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Ambeed

Product number: A189323
Product name: 4-(4-(Trifluoromethyl)phenoxy)benzaldehyde
Purity: 95%
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Ambeed

Product number: A189323
Product name: 4-(4-(Trifluoromethyl)phenoxy)benzaldehyde
Purity: 95%
Packaging: 1g
Price: $225
Updated: 2021/12/16

Crysdot

Product number: CD12011018
Product name: 4-(4-(Trifluoromethyl)phenoxy)benzaldehyde
Purity: 95%
Packaging: 5g
Price: $588
Updated: 2021/12/16

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4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

402-45-9

459-57-4

90035-20-4

Intermediate 52: Synthesis of 4-{[4-(trifluoromethyl)phenyl]oxy}benzaldehyde; To a solution of 4-(trifluoromethyl)phenol (9.1 g, 56 mmol, 1.2 eq.) in N,N-dimethylformamide (DMF, 100 mL) was added sequentially cesium carbonate (22.8 g, 70 mmol, 1.5 eq.) and 4-fluorobenzaldehyde (5 mL, 46.6 mmol, 1.0 equiv). The reaction mixture was stirred and mixed at room temperature, then warmed to 85 °C and stirred continuously for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove the insoluble salt. The filtrate was concentrated under reduced pressure to remove the solvent, and the crude product obtained was purified by fast column chromatography (silica gel, cyclohexane/ethyl acetate=70/30, v/v) to afford the target product 4-(4'-trifluoromethyl)phenoxybenzaldehyde (9.0 g, 73% yield) as a colorless oil. The structure of the product was confirmed by 1H NMR (CDCl3, δ 9.97 (s, 1H), 7.91 (m, 2H), 7.67 (d, J=8.6 Hz, 2H), 7.20-7.11 (m, 4H)) and LCMS ((M+H)+=267, retention time Rt=3.53 min).

References

[1] Patent: WO2010/15652, 2010, A2. Location in patent: Page/Page column 52-53
[2] Patent: WO2009/152082, 2009, A1. Location in patent: Page/Page column 59; 180
[3] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 1, p. 15 - 30
[4] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1801 - 1804
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 7, p. 3036 - 3059

4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE Suppliers

China 32 Germany 1 India 1 United Kingdom 2 United States 2 Global 38

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90035-20-4, 4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDERelated Search:

4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE 3-Methoxy-4-[2-nitro-4-(trifluoromethyl)phenoxy]-benzaldehyde RARECHEM AL BI 0980 1-(4-(2-NITRO-4-(TRIFLUOROMETHYL)PHENOXY)PHENYL)ETHAN-1-ONE 1-(4-(2-NITRO-4-(TRIFLUOROMETHYL)PHENOXY)BENZOYL)-1-PHENYLSEMICARBAZIDE RARECHEM AL BO 1699 3-HYDROXY-4-(2-NITRO-4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE 4-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE METHYL 4-(2-NITRO-4-(TRIFLUOROMETHYL)PHENOXY)BENZOATE 1-[4-(2-CHLORO-6-FLUORO-4-TRIFLUOROMETHYL-PHENOXY)-PHENYL]-ETHANONE 4-[2-Nitro-4-(trifluoromethyl)phenoxy]benzaldehyde METHYL 4-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOXY]BENZENECARBOXYLATE METHYL 4-[2-AMINO-4-(TRIFLUOROMETHYL)PHENOXY]-BENZOATE 4-[4-(TRIFLUOROMETHYL)PHENOXY]BENZOIC ACID RARECHEM AL BE 0980

4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE

Benzaldehyde, 4-[4-(trifluoromethyl)phenoxy]-

90035-20-4