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DPO-1

Product Name
DPO-1
CAS No.
43077-30-1
Chemical Name
DPO-1
Synonyms
DPO-1;DOP-1 (Diphenyl phosphine oxide-1);(+)-Neomenthyl diphenylphosphine oxide;inhibit,DPO1,Inhibitor,DPO 1,Potassium Channel,DPO-1,KcsA;((1S,2S,5R)-2-Isopropyl-5-methylcyclohexyl)diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide;{[(1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl](phenyl)phosphoroso}benzene;Phosphine oxide, [(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-;[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide
CBNumber
CB3850927
Molecular Formula
C22H29OP
Formula Weight
340.44
MOL File
43077-30-1.mol
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DPO-1 Property

storage temp. 
Store at +4°C
solubility 
DMSO: soluble2mg/mL, clear (warmed)
form 
needles
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7443
Product name
DPO-1
Purity
needles, >97% (NMR)
Packaging
25mg
Price
$853
Updated
2023/06/20
Cayman Chemical
Product number
29688
Product name
DPO-1
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
29688
Product name
DPO-1
Packaging
10mg
Price
$227
Updated
2024/03/01
Cayman Chemical
Product number
29688
Product name
DPO-1
Packaging
5mg
Price
$142
Updated
2024/03/01
Tocris
Product number
2533
Product name
DPO-1
Purity
≥99%(HPLC)
Packaging
10
Price
$173
Updated
2021/12/16
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DPO-1 Chemical Properties,Usage,Production

Uses

DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia[1][2].

Definition

ChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid.

Biological Activity

Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

storage

Store at +4°C

References

[1] Lagrutta A, et al. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63. DOI:10.1124/jpet.106.101162
[2] Stump GL, et al. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7. DOI:10.1124/jpet.105.092197

DPO-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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DPO-1 Suppliers

China 46 Germany 1 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 56
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from DPO-1 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
DPO-1 43077-30-1
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-23

43077-30-1, DPO-1Related Search:

CYCLOHEXYLDIPHENYLPHOSPHINE OXIDE DIMETHYLOCTYLPHOSPHINE OXIDE, ANAGRADE? ISOPROPYLDIPHENYLPHOSPHINE OXIDE, 97 (S)-(+)-NEOMENTHYLDIPHENYLPHOSPHINE DPO-1 Cyclohexyldiphenylphosphine

  • DPO-1
  • [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide
  • (+)-Neomenthyl diphenylphosphine oxide
  • (1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
  • DOP-1 (Diphenyl phosphine oxide-1)
  • Phosphine oxide, [(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-
  • inhibit,DPO1,Inhibitor,DPO 1,Potassium Channel,DPO-1,KcsA
  • {[(1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl](phenyl)phosphoroso}benzene
  • ((1S,2S,5R)-2-Isopropyl-5-methylcyclohexyl)diphenylphosphine oxide
  • 43077-30-1
  • C22H29OP