ChemicalBook > CAS DataBase List > 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

Product Name
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
CAS No.
111974-74-4
Chemical Name
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
Synonyms
Quetiapine EP Impurity B;Norquetiapine dihydrochloride salt;QUETIAPINE RC B;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl;11-(1-Piperazinyl)-dibenzo[b;4]thiazepine dihydrochloride;Quetiapine Related CoMpound B
CBNumber
CB3854879
Molecular Formula
C17H18ClN3S
Formula Weight
331.86
MOL File
111974-74-4.mol
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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Property

Melting point:
180-184°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in DMSO, Methanol, Distilled Water
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey
MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES
C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference
111974-74-4(CAS DataBase Reference)
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Safety

HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
KIT1365
Product name
N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol)
Packaging
10x1ml
Price
$145
Updated
2021/12/16
TRC
Product number
D288740
Product name
N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride
Packaging
5g
Price
$155
Updated
2021/12/16
AK Scientific
Product number
J11616
Product name
QuetiapineEPImpurityB2HCl
Packaging
25mg
Price
$39
Updated
2021/12/16
Matrix Scientific
Product number
090783
Product name
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride
Purity
95+%
Packaging
1g
Price
$114
Updated
2021/12/16
Matrix Scientific
Product number
090783
Product name
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride
Purity
95+%
Packaging
5g
Price
$303
Updated
2021/12/16
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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Usage,Production

Description

Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4

Chemical Properties

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid

Uses

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic

Uses

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.

References

1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Suppliers

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View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-22
hebei hongtan Biotechnology Co., Ltd
Product
1-Methylindole-3-carboxaldehyde 111974-74-4
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-22
Hebei Mojin Biotechnology Co., Ltd
Product
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-01-31

111974-74-4, 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochlorideRelated Search:

Quetiapine Carboxylate Impurity 2-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)ethanol dihydrochloride Quetiapine Dimer Impurity 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl Acetate Quetiapine Hydroxy Impurity Quetiapine N-Oxide 1,2-Bis[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethane 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetaMide 2-[2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethoxy]ethanol FuMarate Ethyl Quetiapine Fumarate Salt Quetiapine EP Impurity N DiHCl dibenzo[b,f][1,4]thiazepin-11-amine Quetiapine EP Impurity W Quetiapine Sulfone Quetiapine EP Impurity N Quetiapine EP Impurity C

  • 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP,
  • 11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride
  • Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2)
  • 11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE
  • dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine
  • dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride
  • 11-Piperazinodibenzo-[b,f][1,4]-thiazepin
  • N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl
  • Quetiapine IMpurity A (DBTP Metabolite)
  • Quetiapine DBTP Metabolite
  • 11-PIPERAZYNIL-DIBENZO[B,F][1,4] THIAZEP
  • Quetiapine EP Impurity B DiHCl
  • Quetiapine Impurity 28(Quetiapine EP Impurity B)
  • 11-(1-Piperazinyl)-dibenzo[b
  • 4]thiazepine dihydrochloride
  • Quetiapine Related CoMpound B
  • 11-piperazinyl-dibenzo d,f 1,4 thiazepine dihydrochloride
  • N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1.0 Mg/ML in Methanol)
  • Quetiapine Impurity B DiHCl
  • Quetiapine EP Impurity B
  • 11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
  • 11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride
  • 11-PIPERAZINYL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
  • 11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
  • 11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCl (DBTP)
  • 11-Piperazynil-Dibenzo[b,f][1,4]Thiazepine DIHYDROCHLORIDE
  • DibenzoB,F1,4Thiazepine-11-Piperazine2Hcl
  • 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine,2HCl
  • N-Des[2-(2-hydroxyethoxy)ethyl]Quetiapinedihydrochloride
  • N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazine2HCl
  • N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazinedihydrochloride
  • Dibenzo[b,f][1,4] thiazepine-11-amine Hydrochloride
  • 11-Piperazynil-dibenzo (b,f)(1,4)thiazepine-11-piperazine 2HCl
  • 1-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPINEDIHYDROCHLORIDE
  • 11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
  • 11-(Piperazin-1-yl)dibenzo[b,f][1,4
  • Norquetiapine dihydrochloride
  • 11-Piperazinodibenzo[b,f][1,4]thiazepine DiHCl
  • Norquetiapine dihydrochloride salt
  • 11-Piperazynil-dibenzo[b,f][1,4]thiazepine dihydrochloride (DBTP)
  • Quetiapine Impurity-B/RC-2
  • Quetiapine Fumarate EP Impurity B
  • Quetiapine EP Impurity B/ Quetiapine Related Compound B (Quetiapine DBTP Metabolite)
  • 11-(piperazine-1-yl)dienzo[b,f][1,4]thiazepine hydrochloride
  • 11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride
  • N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine DihydrochlorideQ: What is N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the CAS Number of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the storage condition of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What are the applications of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride
  • 111974-74-4 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
  • 11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine（Quetiapine EP Impurity B)
  • Quetiapine Related Compound B (11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine dihydrochloride) (1592737)
  • Quetiapine Impurity B (EP) DiHCl
  • Quetiapine Related Compound B as Dihydrochloride
  • Quetiapine USP Related Compound B as Dihydrochloride
  • 11-(1-piperazinyl)-Dibenzo[b,f][1,4]thiazepine hydrochloride (1:2)
  • 11-Piperazinodibenzo-[b,f][1,4]-thiazepin dihydrochloride
  • 11-piperazine-dibenzo [b,f][1,4] thiazepine dihydrochloride
  • Quetiapine Fumarate EP Impurity B as Dihydrochloride
  • QuetiapineEPImpurityB2HCl
  • Quetiapine EP Impurity B Dihydrochloride