ChemicalBook > CAS DataBase List > 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

Product Name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
CAS No.: 111974-74-4
Chemical Name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
Synonyms: Quetiapine EP Impurity B;Norquetiapine dihydrochloride salt;QUETIAPINE RC B;Norquetiapine.HCl;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl;11-(1-Piperazinyl)-dibenzo[b;4]thiazepine dihydrochloride
CBNumber: CB3854879
Molecular Formula: C17H18ClN3S
Formula Weight: 331.86
MOL File: 111974-74-4.mol

Less

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Property

Melting point:: 180-184°C
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in DMSO, Methanol, Distilled Water
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey: MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES: C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference: 111974-74-4(CAS DataBase Reference)

Less

Safety

HS Code: 2934990002

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: KIT1365
Product name: N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol)
Packaging: 10x1ml
Price: $145
Updated: 2021/12/16

TRC

Product number: D288740
Product name: N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride
Packaging: 5g
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: J11616
Product name: QuetiapineEPImpurityB2HCl
Packaging: 25mg
Price: $39
Updated: 2021/12/16

Matrix Scientific

Product number: 090783
Product name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride
Purity: 95+%
Packaging: 1g
Price: $114
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000074
Product name: 11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $137.55
Updated: 2021/12/16

Less

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Usage,Production

Description

Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4

Chemical Properties

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid

Uses

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic

Uses

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.

References

[1] A CARLO ALTAMURA. Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.[J]. Clinical Drug Investigation, 2012, 32 3: 213-219. DOI:10.2165/11597330-000000000-00000
[2] FRANCISCO LÓPEZ-MUÑOZ Cecilio A. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders.[J]. Frontiers in Psychiatry, 2013: 102. DOI:10.3389/fpsyt.2013.00102
[3] BARBARA DI BENEDETTO . N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant[J]. Neuropharmacology, 2012, 62 1: Pages 209-216. DOI:10.1016/j.neuropharm.2011.07.001
[4] CARL BJÖRKHOLM . Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine[J]. European Neuropsychopharmacology, 2013, 23 7: Pages 709-720. DOI:10.1016/j.euroneuro.2012.05.012

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Suppliers

Canada 2 China 215 Europe 1 France 1 Germany 2 India 18 United Kingdom 2 United States 25 Global 266

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6948
Advantage: 52

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Yangzhou Hopechem Co., Ltd.

Tel: 15062859468
Fax: QQ:1719657062，MSN:quality.kate@hotmail.com
Country: China
ProdList: 100
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 896
Advantage: 55

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7782
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Shanghai yongzeng technology co., LTD

Tel: 021-021-021-65281118 15921781258
Fax: 021-6528 2963
Email: sales@yongzchem.com
Country: China
ProdList: 69
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Artis Biotech Co. Ltd.

Tel: 028-67271278 18628360895
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 1960
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Tonichem Pharmaceutical Technology Co., Ltd.

Tel: +86 (0752) 222-7171, +86 15815821171
Fax: +86 (0752) 222-6171
Country: China
ProdList: 1120
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 17801761073
Email: 3193328036@qq.com
Country: China
ProdList: 6338
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@yongstandards.com
Country: China
ProdList: 10000
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9756
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Shanghai Orgchem Co.,Ltd.

Tel: +86-21-5877 1921
Fax: +86-21-5877 1925
Email: info@chemofchina.com
Country: China
ProdList: 9653
Advantage: 55

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2389
Advantage: 58

Less

View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Qiuxian Baitai New Material Co., LTD

Product: 11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride 111974-74-4
Price: US $1.50/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-12-21

Career Henan Chemical Co

Product: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-20

111974-74-4, 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochlorideRelated Search:

Quetiapine Carboxylate Impurity 2-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)ethanol dihydrochloride Quetiapine Dimer Impurity 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl Acetate Quetiapine Hydroxy Impurity Quetiapine N-Oxide 1,2-Bis[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethane 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetaMide 2-[2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethoxy]ethanol FuMarate Ethyl Quetiapine Fumarate Salt Quetiapine EP Impurity N DiHCl dibenzo[b,f][1,4]thiazepin-11-amine Quetiapine EP Impurity W Quetiapine Sulfone Quetiapine EP Impurity N Quetiapine EP Impurity C

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP,

11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride

Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2)

11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE

dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine

dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride

11-Piperazinodibenzo-[b,f][1,4]-thiazepin

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl

Quetiapine IMpurity A (DBTP Metabolite)

Quetiapine DBTP Metabolite

11-PIPERAZYNIL-DIBENZO[B,F][1,4] THIAZEP

Quetiapine EP Impurity B DiHCl

Quetiapine Impurity 28(Quetiapine EP Impurity B)

11-(1-Piperazinyl)-dibenzo[b

4]thiazepine dihydrochloride

Quetiapine Related CoMpound B

11-piperazinyl-dibenzo d,f 1,4 thiazepine dihydrochloride

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1.0 Mg/ML in Methanol)

Quetiapine Impurity B DiHCl

Quetiapine EP Impurity B

11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride

11-PIPERAZINYL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL

11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL

11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCl (DBTP)

11-Piperazynil-Dibenzo[b,f][1,4]Thiazepine DIHYDROCHLORIDE

DibenzoB,F1,4Thiazepine-11-Piperazine2Hcl

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine,2HCl

N-Des[2-(2-hydroxyethoxy)ethyl]Quetiapinedihydrochloride

N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazine2HCl

N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazinedihydrochloride

Dibenzo[b,f][1,4] thiazepine-11-amine Hydrochloride

11-Piperazynil-dibenzo (b,f)(1,4)thiazepine-11-piperazine 2HCl

1-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPINEDIHYDROCHLORIDE

11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL

11-(Piperazin-1-yl)dibenzo[b,f][1,4

Norquetiapine dihydrochloride

11-Piperazinodibenzo[b,f][1,4]thiazepine DiHCl

Norquetiapine dihydrochloride salt

11-Piperazynil-dibenzo[b,f][1,4]thiazepine dihydrochloride (DBTP)

Quetiapine Impurity-B/RC-2

Quetiapine Fumarate EP Impurity B

Quetiapine EP Impurity B/ Quetiapine Related Compound B (Quetiapine DBTP Metabolite)

11-(piperazine-1-yl)dienzo[b,f][1,4]thiazepine hydrochloride

11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine DihydrochlorideQ: What is N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the CAS Number of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the storage condition of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What are the applications of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride

111974-74-4 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine（Quetiapine EP Impurity B)

Quetiapine Related Compound B (11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine dihydrochloride) (1592737)

Quetiapine Impurity B (EP) DiHCl

Quetiapine Related Compound B as Dihydrochloride

Quetiapine USP Related Compound B as Dihydrochloride

11-(1-piperazinyl)-Dibenzo[b,f][1,4]thiazepine hydrochloride (1:2)

11-Piperazinodibenzo-[b,f][1,4]-thiazepin dihydrochloride

11-piperazine-dibenzo [b,f][1,4] thiazepine dihydrochloride

Quetiapine Fumarate EP Impurity B as Dihydrochloride

QuetiapineEPImpurityB2HCl

Quetiapine EP Impurity B Dihydrochloride