3-Amino-5-methoxyisoxazole
- Product Name
- 3-Amino-5-methoxyisoxazole
- CAS No.
- 32326-25-3
- Chemical Name
- 3-Amino-5-methoxyisoxazole
- Synonyms
- 5-methoxy-3-isoxazolamine;5-methoxyisoxazol-3-amine;3-Amino-5-methoxisoxazole;3-AMINE-5-METHOXYISOXAZOLE;3-Amino-5-methoxyisoxazole;3-Isoxazolamine, 5-methoxy-;5-Methoxy-isoxazol-3-ylamine;5-Methoxy-1,2-oxazol-3-aMine
- CBNumber
- CB3855447
- Molecular Formula
- C4H6N2O2
- Formula Weight
- 114.1
- MOL File
- 32326-25-3.mol
3-Amino-5-methoxyisoxazole Property
- Boiling point:
- 282°C
- Density
- 1.243
- Flash point:
- 124°C
- storage temp.
- 2-8°C(protect from light)
- pka
- 1.85±0.10(Predicted)
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M268528
- Product name
- 5-Methoxyisoxazol-3-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR952969
- Product name
- 3-Amino-5-methoxyisoxazole
- Purity
- 97%
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR952969
- Product name
- 3-Amino-5-methoxyisoxazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 072812
- Product name
- 5-Methoxyisoxazol-3-amine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- OR952969
- Product name
- 3-Amino-5-methoxyisoxazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $465
- Updated
- 2021/12/16
3-Amino-5-methoxyisoxazole Chemical Properties,Usage,Production
Uses
5-Methoxyisoxazol-3-amine is a useful reactant in the synthesis of pyrazolidine derivatives and 1-substituted tetrazoles via cyclization of amines.
Synthesis
15732-02-2
32326-25-3
Hydroxylamine hydrochloride (1.55 g, 22.3 mmol) was dissolved in water (3.41 mL) under stirring conditions at room temperature, followed by the slow addition of aqueous 8 N sodium hydroxide (3.35 mL, 26.8 mmol). The reaction system was warmed up to 45 °C and a methanol (5.50 mL) solution of 3,3-dimethoxyacrylonitrile (2.27 g, 20.1 mmol) was added dropwise at this temperature for 30 min. After the dropwise addition, the reaction was kept at 45 °C with continued stirring for 1 hour. After confirming the complete consumption of 3,3-dimethoxyacrylonitrile by TLC monitoring, 8 N aqueous sodium hydroxide solution (1.25 mL, 10.1 mmol) was added to the reaction system and the temperature was raised to 60 °C and the reaction continued to be stirred for 6 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure at 60 °C and 19 mmHg until the inorganic salt began to precipitate. The concentrated product was extracted with ethyl acetate (5 mL × 3), and the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure and the residue was further dried under reduced pressure to give white crystals of 3-amino-5-methoxyisoxazole (1.63 g, 70.6% yield). The melting point of the product was 82-83 °C (hexane-ethyl acetate recrystallization). NMR hydrogen spectrum (CDCl3) data: δ 3.93 (5H, broad peak, CH3 + NH2), 4.81 (1H, single peak, H-4); NMR hydrogen spectrum (CDCl3 + D2O) data: δ 3.93 (3H, single peak, CH3), 4.83 (1H, single peak, H-4). Infrared spectra (CHCl3) major absorption peaks: 3840, 1628, 1487 cm-1. Elemental analysis (calculated values, C4H6N2O2): C, 42.11%; H, 5.30%; N, 24.55%. Measured values: C, 41.74%; H, 5.06%; N, 24.35%.
References
[1] Bulletin of the Chemical Society of Japan, 1994, vol. 67, # 6, p. 1701 - 1707
[2] Patent: US5585494, 1996, A
3-Amino-5-methoxyisoxazole Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Amino-5-methoxyisoxazole manufacturers
- Product
- 3-Amino-5-methoxyisoxazole 32326-25-3
- Price
- US $1.80-3.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 88KG
- Release date
- 2019-09-04