oxprenolol
- Product Name
- oxprenolol
- CAS No.
- 6452-71-7
- Chemical Name
- oxprenolol
- Synonyms
- Coretal;Tevacor;Oxenalol;Aids001596;Aids-001596;dl-Oxprenolol;Oxprenolol-d7;oxprenolol USP/EP/BP;Coretal (hydrochloride);6452-73-9 (Hydrochloride)
- CBNumber
- CB3875564
- Molecular Formula
- C15H23NO3
- Formula Weight
- 265.35
- MOL File
- 6452-71-7.mol
oxprenolol Property
- Melting point:
- 78-80°
- Boiling point:
- 408.57°C (rough estimate)
- Density
- 1.0479 (rough estimate)
- refractive index
- 1.5000 (estimate)
- solubility
- Dichloromethane (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.89±0.20(Predicted)
- color
- White to Off-White
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- RDL0007030
- Product name
- OXPRENOLOL-D7
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.25
- Updated
- 2021/12/16
oxprenolol Chemical Properties,Usage,Production
Description
Oxprenolol induced contact dermatitis in a worker at a pharmaceutical plant, in the division for drug synthesis. Epichlorhydrin was also used for the production of both propranolol and oxprenolol.
Originator
Trasicor,Ciba Geigy ,Italy,1970
Uses
Oxprenolol is a free base of Oxprenolol Hydrochloride(O870500) which is a β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Uses
Vasodilator(coronary).
Definition
ChEBI: 1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol is an aromatic ether.
Manufacturing Process
75 grams of pyrocatechol monoallyl ether, 75 grams of epichlorohydrin, 75 grams of potassium carbonate and 400 ml of acetone are stirred and heated at the boil for 12 hours. The potassium carbonate is then filtered off. The solvent is distilled off in a water-jet vacuum. The residual oil is dissolved in ether and agitated with 2 N sodium hydroxide solution. The ether is separated, dried and distilled off. The residue is distilled in a water-jet vacuum. 3-(ortho-allyloxy-phenoxy)-1,2-epoxypropane passes over at 145° to 157°C under 11 mm Hg pressure. A solution of 15 grams of 3-(ortho-allyloxyphenoxy)-1,2-epoxypropane and 15 grams of isopropylamine in 20 ml of ethanol is refluxed for 4 hours. The excess amine and the alcohol are then distilled off under vacuum, to leave 1-isopropylamino-2-hydroxy-3-(orthoallyloxy-phenoxy)-propane which melts at 75° to 80°C after recrystallization from hexane.
brand name
Trasicor (Novartis).
Therapeutic Function
Antiarrhythmic
Contact allergens
The beta-blocker oxprenolol induced contact dermatitis in a worker at a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was also used for the production of drugs propranolol and oxprenolol.
oxprenolol Preparation Products And Raw materials
Raw materials
Preparation Products
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