formocortal
- Product Name
- formocortal
- CAS No.
- 2825-60-7
- Chemical Name
- formocortal
- Synonyms
- FI-6341;DeflaMin;Fluderma;Deflamene;Cutisterol;Cortocin F;NSC 150527;formocortal;FluoforMylon;Fluoroformylon
- CBNumber
- CB3886160
- Molecular Formula
- C29H38ClFO8
- Formula Weight
- 569.06
- MOL File
- 2825-60-7.mol
formocortal Property
- Melting point:
- 180-182°
- alpha
- D20 +26° (chloroform)
- Density
- 1.2000 (estimate)
Safety
- Toxicity
- LD50 in mice: >2000 mg/kg orally; 490 mg/kg s.c.; 537 mg/kg i.p. (Bertazzoli)
N-Bromosuccinimide Price
- Product number
- F693100
- Product name
- Formocortal
- Packaging
- 50mg
- Price
- $1540
- Updated
- 2021/12/16
- Product number
- API0011517
- Product name
- FORMOCORTAL
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $350
- Updated
- 2021/12/16
- Product number
- API0011517
- Product name
- FORMOCORTAL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $816.75
- Updated
- 2021/12/16
- Product number
- API0011517
- Product name
- FORMOCORTAL
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $2194.5
- Updated
- 2021/12/16
formocortal Chemical Properties,Usage,Production
Originator
Fluderma,Farmitalia,Italy,1970
Uses
formocortal is a corticosteroid with antiinflammatory activity used in ophthalmology.
Definition
ChEBI: Formocortal is a steroid. It derives from a hydride of a pregnane.
Manufacturing Process
4.8 grams of 9α-fluoro-4-pregnene-11β,16α,17α,21-tetrol-3,20-dione-21-
acetate-16α,17α-acetonide, melting at 248° to 250°C and prepared by
acetylation of the corresponding 21-alcohol (J. Amer. Chem. Soc., 1959, 81,
page 1689), were refluxed for 20 hours with 80 cc of dioxane, 5.2 cc of
ethylene glycol, 4.8 cc of ethyl orthoformate and 60 mg of p-toluenesulfonic
acid. After cooling, 0.6 cc of pyridine were added and the mixture was
concentrated in vacuo, diluted with ethyl acetate, poured into a separatory
funnel, and washed with water, with a solution of 5% aqueous sodium
bicarbonate and then with water to neutrality. After distilling off the solvent, a
residue of 5.5 grams remained, which was dissolved in benzene and
chromatographed over 100 grams of Florisil (chromatographic adsorbent). 3
grams of 9α-fluoro-5-pregnene-11β,16α,17α,21-tetrol-3,20-dione-21-acetate-
3-ethyleneketal-16α,17α-acetonide, melting at 145° to 147°C, were collected
from the fractions eluted with benzene-ether 9:1.
1 gram of this 9α-fluoro-5-pregnene-11β,16α,17α,21-tetrol-3,20-dione-21-
acetate-3-ethyleneketal-16α,17α-acetonide in 2 cc of dimethylformamide and
2 cc of trichloroethylene was heated for 3 hours on an oil bath at 70°C with
the reagent obtained from 0.5 cc of dimethylformamide in 4 cc of
trichloroethylene with 0.5 cc phosphorus oxychloride. After cooling to 0°C, 1
gram of sodium acetate dissolved in 3 cc of water were slowly added with
stirring. The mixture was extracted with ethyl acetate and the extracts were
washed with water, with a 5% aqueous solution of sodium bicarbonate and
then with water to neutrality. On distillation of the solvent 1.1 grams of a
residue was obtained from which, after dissolution in ether and precipitation
with petroleum ether, 0.500 gram of 3-(2'-chloroethoxy)-6-formyl-9α-fluoro-
3,5-pregnadien-11β,16α,17α,21-tetrol-20-one-21-acetate-16α,17α-acetonide,
melting at 180° to 182°C were obtained.
Therapeutic Function
Glucocorticoid, Antiinflammatory
formocortal Preparation Products And Raw materials
Raw materials
Preparation Products
formocortal Suppliers
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- Country
- United States
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