ChemicalBook > CAS DataBase List > 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride

4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride

Product Name
4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride
CAS No.
2015-28-3
Chemical Name
4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride
Synonyms
PERPHENAZINE HCL;Perphenazine hydrochloride;4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride;Perphenazine D8 DihydrochlorideQ: What is Perphenazine D8 Dihydrochloride Q: What is the CAS Number of Perphenazine D8 Dihydrochloride Q: What is the storage condition of Perphenazine D8 Dihydrochloride Q: What are the applications of Perphenazine D8 Dihydrochloride
CBNumber
CB3893748
Molecular Formula
C21H28Cl3N3OS
Formula Weight
476.89052
MOL File
2015-28-3.mol
More
Less

4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Property

color 
Crystals
More
Less

Safety

Toxicity
LD50 orl-rat: 318 mg/kg 27ZQAG -,36,72
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Chemical Properties,Usage,Production

Uses

Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer cell proliferation, and induces apoptosis. Perphenazine dihydrochloride can be used in the research of mental disease, cancer, inflammation[1][3][5].

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and intramuscular routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits very toxic fumes of Clí, NOx, SOx, and HCl.

in vivo

Perphenazine (oral gavage, 180 mg/kg, every other day for 21 days) dihydrochloride induces liver injury and lysosomal membrane damage in ICR mice[2].
Perphenazine (oral administration, 10 mg/kg, every other day for 6 days) dihydrochloride attenuates morphological phenotype in mouse models of Th2-type allergic dermatitis[3].

Animal Model:ICR mice[2]
Dosage:10, 30, 60, 120, 180 mg/kg
Administration:Oral gavage, every other day for 21 days.
Result:Increased histological injury and aminotransferases compared with control.
Animal Model:Oxazolone-treated animal model of dermatitis[3]
Dosage:10 mg/kg
Administration:Oral administration, every other day for 6 days
Result:Decreased The levels of mice ear swelling.

IC 50

D2 Receptor: 0.56 nM (Ki); D3 Receptor: 0.43 nM (Ki); D4 Receptor: 28.5 nM (Ki); 5-HT2A Receptor: 5.6 nM (Ki); 5-HT6 Receptor: 17 nM (Ki); 5-HT7 Receptor: 23 nM (Ki); 5-HT2C Receptor: 132 nM (Ki); 5-HT1A Receptor: 421 nM (Ki)

References

[1] Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32(8):1715-26. DOI:10.1038/sj.npp.1301305
[2] Lei Tao, et al. Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo. Toxicol Lett. 2022 Jul 29;367:76-87. DOI:10.1016/j.toxlet.2022.07.814
[3] Min-Jeong Heo, et al. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis. Int J Mol Sci. 2020 May 3;21(9):3241. DOI:10.3390/ijms21093241
[4] Micha? Otr?ba, et al. Perphenazine and prochlorperazine decrease glioblastoma U-87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters, E-cadherin, α-tubulin and integrins (α3, α5, and β1) levels. Oncol Lett. 2022 Jun;23(6):182. DOI:10.3892/ol.2022.13302
[5] Micha? Otr?ba, et al. n vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review. J Appl Toxicol. 2021 Jan;41(1):82-94. DOI:10.1002/jat.4046

4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Suppliers

China 11 Finland 2 India 1 Global 14
Tianjin shijia biomedical technology co., LTD
Tel
15022261580 15022261580;
Email
tjshj1212@163.com
Country
China
ProdList
2697
Advantage
58
Manhag Testing Technology Co., Ltd
Tel
020-3846 2365 19110442770
Email
458677837@qq.com
Country
China
ProdList
7775
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
029-029-81120477 17792793610
Email
1033@dideu.com
Country
China
ProdList
9935
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
ProdList
12582
Advantage
58
SHANGHAI ZZBIO CO., LTD.
Tel
15102117276 19921389125
Email
tech@zzbioco.com
Country
China
ProdList
12064
Advantage
58
BePure (Beijing) Biotechnology Co.
Tel
58896805
Email
7993601name@qq.com
Country
CHINA
ProdList
6620
Advantage
58
nanjing
Tel
13376082704 13376084917;
Email
3930959291@qq.com
Country
China
ProdList
2080
Advantage
58
Shanghai meikai technology co., ltd
Tel
021-68689288 15300790979
Fax
wechat 18721550091
Email
info@mkbio.com.cn
Country
China
ProdList
5000
Advantage
58

2015-28-3, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Related Search:

PERPHENAZINE

  • 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride
  • PERPHENAZINE HCL
  • Perphenazine hydrochloride
  • Perphenazine D8 DihydrochlorideQ: What is Perphenazine D8 Dihydrochloride Q: What is the CAS Number of Perphenazine D8 Dihydrochloride Q: What is the storage condition of Perphenazine D8 Dihydrochloride Q: What are the applications of Perphenazine D8 Dihydrochloride
  • 2015-28-3