methyl 5-methoxy-2-methyl-1H-indole-3-acetate
- Product Name
- methyl 5-methoxy-2-methyl-1H-indole-3-acetate
- CAS No.
- 7588-36-5
- Chemical Name
- methyl 5-methoxy-2-methyl-1H-indole-3-acetate
- Synonyms
- ZIDO-001;Einecs 231-497-4;5-Methoxy-2-Methyl-;Acrylamide Impurity 21;Methyl 5-Methoxy-2-methylindole-3-acetate;Eethyl 5-methoxy-2-methyl-1H-indole-3-acetate;methyl 5-methoxy-2-methyl-1H-indole-3-acetate;5-Methoxy-2-methyl-1H-indole-3-acetic acid methyl ester;1H-Indole-3-acetic acid,5-methoxy-2-methyl-,methyl ester
- CBNumber
- CB3893773
- Molecular Formula
- C13H15NO3
- Formula Weight
- 233.26
- MOL File
- 7588-36-5.mol
methyl 5-methoxy-2-methyl-1H-indole-3-acetate Property
- Melting point:
- 65-68°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate, Methanol
- form
- Solid
- color
- Beige
- InChI
- InChI=1S/C13H15NO3/c1-8-10(7-13(15)17-3)11-6-9(16-2)4-5-12(11)14-8/h4-6,14H,7H2,1-3H3
- InChIKey
- JYUNCKSXPPDNRM-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(OC)C=C2)C(CC(OC)=O)=C1C
N-Bromosuccinimide Price
- Product number
- M320480
- Product name
- Methyl5-Methoxy-2-methylindole-3-acetate
- Packaging
- 25mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 5447CA
- Product name
- Methyl2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- A214681
- Product name
- Methyl2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- A214681
- Product name
- Methyl2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- A214681
- Product name
- Methyl2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
methyl 5-methoxy-2-methyl-1H-indole-3-acetate Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of Indomethacin
Synthesis
67-56-1
2882-15-7
7588-36-5
General method: 5-methoxy-2-methyl-3-indoleacetic acid (1 eq.) was dissolved with BOP-Cl (1 eq.) in anhydrous CH2Cl2 (3 mL/mmol), triethylamine (2 eq.) was added, and the reaction was carried out for 5 min at room temperature. Subsequently, anhydrous methanol (0.14 mL/mmol) was added and stirred overnight at room temperature. After completion of the reaction, the reaction mixture was diluted with dichloromethane (12 mL/mmol), washed with water (2 x 6 mL/mmol), dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated under reduced pressure, and the resulting crude product was purified by rapid chromatography on silica gel (gradient elution with ethyl acetate/hexane) to afford methyl 5-methoxy-2-methyl-1H-indole-3-acetate, which was initially a yellow viscous oil, and crystallized and solidified after inoculation and refrigeration.
References
[1] Tetrahedron, 2012, vol. 68, # 48, p. 10049 - 10058,10
[2] Tetrahedron, 2012, vol. 68, # 48, p. 10049 - 10058
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 3, p. 1202 - 1218
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 15, p. 4830 - 4837
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 8, p. 1810 - 1827
methyl 5-methoxy-2-methyl-1H-indole-3-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from methyl 5-methoxy-2-methyl-1H-indole-3-acetate manufacturers
- Product
- methyl 5-methoxy-2-methyl-1H-indole-3-acetate 7588-36-5
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12