ChemicalBook > CAS DataBase List > Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-

Product Name
Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-
CAS No.
1923844-48-7
Chemical Name
Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-
Synonyms
BMS-986242;BMS-986242, 10 mM in DMSO;4-Chloro-N-((R)-1-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)benzamide;Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-;4-chloro-N-[(1R)-1-[(1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl]ethyl]benzamide;glucuronidation,potent,Indoleamine 2,3-Dioxygenase (IDO),cancer,Inhibitor,BMS 986242,inhibit,BMS-986242,active,selective,orally
CBNumber
CB39008426
Molecular Formula
C24H24ClFN2O
Formula Weight
410.91
MOL File
1923844-48-7.mol
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Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Property

Boiling point:
593.0±40.0 °C(Predicted)
Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (608.41 mM; Need ultrasonic)
form 
Solid
pka
14.09±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Chemical Properties,Usage,Production

Uses

BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer[1].

Biological Activity

BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer[1]. BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ～20 % max inhibition)[1]. BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses[1].

in vivo

BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses[1].

Animal Model:nu/nu Mouse[1]
Dosage:3~30 mg/kg
Administration:P.o.
Result:Exhibited dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses.

IC 50

IDO1

References

[1]. Cherney EC, et al. Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1. ACS Med Chem Lett. 2021;12(2):288-294. Published 2021 Jan 28.

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Suppliers

China 27 United States 4 Global 31
BOC Sciences
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1923844-48-7, Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-Related Search:


  • Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-
  • BMS-986242
  • glucuronidation,potent,Indoleamine 2,3-Dioxygenase (IDO),cancer,Inhibitor,BMS 986242,inhibit,BMS-986242,active,selective,orally
  • 4-chloro-N-[(1R)-1-[(1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl]ethyl]benzamide
  • BMS-986242, 10 mM in DMSO
  • 4-Chloro-N-((R)-1-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)benzamide
  • 1923844-48-7