5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride

Product Name
5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
CAS No.
18059-99-9
Chemical Name
5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
Synonyms
LM-2909;Deparon hydrochloride;demexiptiline hydrochloride;5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
CBNumber
CB3914472
Molecular Formula
C18H19ClN2O
Formula Weight
314.80926
MOL File
18059-99-9.mol
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5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Property

Melting point:
232-233°
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Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in rats (mg/kg): 330 orally, 25 i.v. (Rossi)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D231585
Product name
DemexiptilineHydrochloride
Packaging
10mg
Price
$310
Updated
2021/12/16
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5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Chemical Properties,Usage,Production

Originator

Deparon,Aron,France,1981

Uses

Demexiptiline Hydrochloride is a tricyclic antidepressant that can also serve as a new potential antibacterial agent.

Manufacturing Process

1.15 g of Na are dissolved in 100 ml of absolute ethanol; 10 g of 5-oximino5H-dibenzo[a,d]cycloheptene are introduced, followed by boiling under reflux for 1 hour and evaporation to dryness. The residue is dissolved in dimethylformamide and part of the solvent is distilled off. The solution is now cooled to about 20°C and there are added 5.3 g of methylaminoethyl chloride which is prepared below 10°C from the corresponding hydrochloride by supersaturation with potassium carbonate. The mixture is then heated to 100°C for 1? hours. Finally, the mixture is evaporated to dryness, the residue dissolved in ether/water and the ethereal phase washed with water. After drying of the ethereal phase with potassium carbonate, 8.5 g of the hydrochloride of 5-β-methylaminoethoxyimino-5H-dibenzo[a,d]cycloheptene (melting point 232°C to 233°C) are obtained.

Therapeutic Function

Antidepressant

5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Suppliers

18059-99-9, 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochlorideRelated Search:


  • 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
  • demexiptiline hydrochloride
  • Deparon hydrochloride
  • LM-2909
  • 18059-99-9