10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- Product Name
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- CAS No.
- 2975-36-2
- Chemical Name
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- Synonyms
- Mepazine hydrochloride;10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride;10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride;10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride
- CBNumber
- CB3921722
- Molecular Formula
- C19H23ClN2S
- Formula Weight
- 346.91732
- MOL File
- 2975-36-2.mol
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Property
- Melting point:
- 180-181 °C
- Boiling point:
- 180-183 °C(Press: 0.5 Torr)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 50 mg/mL (144.13 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 5.00500
- Product name
- MALT1InhibitorII,MepazineHydrochloride-CAS2975-36-2-Calbiochem
- Packaging
- 25mg
- Price
- $233
- Updated
- 2023/01/07
- Product number
- CS-0111531
- Product name
- Mepazine(hydrochloride)
- Purity
- 98.29%
- Packaging
- 100mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- CS-0111531
- Product name
- Mepazine(hydrochloride)
- Purity
- 98.29%
- Packaging
- 250mg
- Price
- $455
- Updated
- 2021/12/16
- Product number
- CS-0111531
- Product name
- Mepazine(hydrochloride)
- Purity
- 98.29%
- Packaging
- 25mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CS-0111531
- Product name
- Mepazine(hydrochloride)
- Purity
- 98.29%
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Chemical Properties,Usage,Production
Originator
Pacatal,Warner Lambert,US,1957
Manufacturing Process
A 500 cc flask equipped with a mechanical stirrer, reflux condenser and a soda-lime tube was filled with 230 cc of absolute xylene, 27.5 g of 1-methyl3-bromomethylpiperidine, 53.3 g of phenothiazine and 14.2 g of finely powdered sodium amide, and the solution was heated under reflux for 6 hours. After cooling water was added and the batch was extracted with ether. As the hydrochloric acid salt of the obtained phenothiazine derivative is difficultly soluble in water, the further processing was carried out by way of the acetate. The etheric solution was extracted several times in a separating funnel with dilute acetic acid. The combined aqueous extracts were basified, extracted with ether, dried with potassium carbonate and, after removal of the ether, distilled in vacuo.
Yield = 64%; boiling point 230°C to 235°C at 4 mm; melting point of
hydrochloride is 180°C to 181°C.
Therapeutic Function
Tranquilizer
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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