1-(chloromethyl)-4-(phenylthio)benzene
- Product Name
- 1-(chloromethyl)-4-(phenylthio)benzene
- CAS No.
- 1208-87-3
- Chemical Name
- 1-(chloromethyl)-4-(phenylthio)benzene
- Synonyms
- NSC 43056;1-(Chloromethyl)-4-(phenylsulfanyl);1-(chloromethyl)-4-(phenylthio)benzene;1-(chloromethyl)-4-phenylsulfanylbenzene;Benzene, 1-(chloromethyl)-4-(phenylthio)-;(4-(Chloromethyl)phenyl)(phenyl)sulfane 2:CAS No: 10-25 gm;4-phenyl thio benzyl chloride (4-(chloromethyl)phenyl)(phenyl)sulfane
- CBNumber
- CB3925629
- Molecular Formula
- C13H11ClS
- Formula Weight
- 234.74
- MOL File
- 1208-87-3.mol
1-(chloromethyl)-4-(phenylthio)benzene Property
- Boiling point:
- 372℃
- Density
- 1.22
- Flash point:
- 167℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Yellow to brown Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C371415
- Product name
- (4-(Chloromethyl)phenyl)(phenyl)sulfane
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C371415
- Product name
- (4-(Chloromethyl)phenyl)(phenyl)sulfane
- Packaging
- 5g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- C371415
- Product name
- (4-(Chloromethyl)phenyl)(phenyl)sulfane
- Packaging
- 2.5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3649AA
- Product name
- (4-(Chloromethyl)phenyl)(phenyl)sulfane
- Packaging
- 10g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 099881
- Product name
- (4-(Chloromethyl)phenyl)(phenyl)sulfane
- Purity
- 95+%
- Packaging
- 1g
- Price
- $639
- Updated
- 2021/12/16
1-(chloromethyl)-4-(phenylthio)benzene Chemical Properties,Usage,Production
Uses
(4-(Chloromethyl)phenyl)(phenyl)sulfane can be used as reactant/reagent in preparation of fenticonazole nitrate by phase transfer-catalyzed benzylation of (dichlorophenyl)imidazoleethanol with (phenylthio)benzyl chloride.
Synthesis
6317-56-2
1208-87-3
The general procedure for the synthesis of 4-phenylthiobenzyl chloride from 4-phenylthiobenzyl alcohol was as follows: 518.0 g of 4-phenylthiobenzyl alcohol, 147 mL of pyridine, and 2444 mL of dichloromethane were added to a 5000 mL reaction flask at room temperature (25 °C), mixed well, and then cooled in an ice-water bath to control the temperature. Thionyl chloride was slowly added dropwise at 20-24 °C, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature (25 °C) for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was hexane: ethyl acetate = 10:1) until the reaction was completed. After completion of the reaction, the reaction mixture was washed with water and subsequently neutralized with water and dried with anhydrous magnesium sulfate. The dried mixture was filtered and the filtrate was concentrated to dryness under reduced pressure (pressure 1720 Pa, temperature 25 °C). After recovery of dichloromethane, 548.0 g of brownish red oily product was obtained in 97.7% yield and 99.66% HPLC purity. The product can be cured by freezing to about -10°C.
References
[1] Patent: CN107573288, 2018, A. Location in patent: Paragraph 0016; 0024
[2] Patent: CN107652238, 2018, A. Location in patent: Paragraph 0026; 0027
[3] Arzneimittel-Forschung/Drug Research, 1982, vol. 31, # 12, p. 2123 - 2126
[4] Arzneimittel-Forschung/Drug Research, 1981, vol. 31, # 12, p. 2127 - 2133
[5] Patent: US5420128, 1995, A
1-(chloromethyl)-4-(phenylthio)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
1-(chloromethyl)-4-(phenylthio)benzene Suppliers
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- 021-31261262/ 49 (0)17662837245
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View Lastest Price from 1-(chloromethyl)-4-(phenylthio)benzene manufacturers
- Product
- 1-(chloromethyl)-4-(phenylthio)benzene 1208-87-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2025-04-29
- Product
- 1-(chloromethyl)-4-(phenylthio)benzene 1208-87-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-11
- Product
- 1-(chloromethyl)-4-(phenylthio)benzene 1208-87-3
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28