(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride

Product Name: (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
CAS No.: 38176-02-2
Chemical Name: (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
Synonyms: LU 33925;NSC 632821;CCRIS 2680;R-Verapamil HCl;D7-R-Verapamil HCL;Verapamil impurity 31;Dexverapamil monohydrochloride;R(+)-Verapamil monohydrochloride;R(+)-Verapamil monohydrochloride hydrate;R(+)-Verapamil hydrate monohydrochloride
CBNumber: CB3931684
Molecular Formula: C27H41ClN2O5
Formula Weight: 509.07784
MOL File: 38176-02-2.mol

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(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Property

Melting point:: 129-131?C
storage temp.: Refrigerator
solubility: H2O: >30mg/mL
form: powder
color: white
optical activity: [α]22/D +9.6°, c = 0.5 in ethanol(lit.)
Water Solubility: H2O: >30mg/mL
ethanol: soluble

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V106
Product name: R(+)-Verapamil monohydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $276
Updated: 2025/07/31

Sigma-Aldrich

Product number: V106
Product name: R(+)-Verapamil monohydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $1040
Updated: 2025/07/31

TRC

Product number: V124990
Product name: (R)-(+)-VerapamilHydrochloride
Packaging: 2mg
Price: $335
Updated: 2021/12/16

ChemScene

Product number: CS-0111666
Product name: (R)-Verapamil(hydrochloride)
Purity: 98.54%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ID28684
Product name: (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride
Packaging: 1mg
Price: $318
Updated: 2021/12/16

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(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Chemical Properties,Usage,Production

Chemical Properties

Colourless solid

Uses

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.

Uses

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Definition

ChEBI: Dexverapamil hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. It has a role as an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It contains a dexverapamil(1+). It is an enantiomer of a (S)-verapamil hydrochloride.

Biochem/physiol Actions

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Suppliers

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38176-02-2, (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chlorideRelated Search:

(+/-)-Verapamil hydrochloride Verapamil

R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE

Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI)

Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (R)-

Dexverapamil monohydrochloride

LU 33925

NSC 632821

Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-

Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (R)-

R-Verapamil HCl

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride

R(+)-Verapamil hydrate monohydrochloride

(+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6-

(αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride

R(+)-Verapamil monohydrochloride hydrate

R(+)-Verapamil monohydrochloride

CCRIS 2680

Verapamil impurity 31

D7-R-Verapamil HCL

38176-02-2

C27H38N2O4HClH2O

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