ChemicalBook > CAS DataBase List > 4-chloropyridine

4-chloropyridine

Product Name
4-chloropyridine
CAS No.
626-61-9
Chemical Name
4-chloropyridine
Synonyms
Pyridine, 4-chloro-;gamma-Chloropyridine;Trazodone Impurity 31;4-chloropyridine ISO 9001：2015 REACH
CBNumber
CB3937772
Molecular Formula
C5H4ClN
Formula Weight
113.54
MOL File
626-61-9.mol
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4-chloropyridine Property

Melting point:
-43.5°C
Boiling point:
147℃
Density 
1.200
refractive index 
1.5304 (estimate)
Flash point:
53℃
pka
3.18±0.10(Predicted)
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Safety

Hazardous Substances Data
626-61-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific
Product number
133694
Product name
4-Chloropyridine
Purity
95%+
Packaging
500mg
Price
$365
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0101467
Product name
4-CHLOROPYRIDINE
Purity
95.00%
Packaging
5MG
Price
$505.78
Updated
2021/12/16
Matrix Scientific
Product number
133694
Product name
4-Chloropyridine
Purity
95%+
Packaging
1g
Price
$645
Updated
2021/12/16
Alichem
Product number
626619
Product name
4-Chloropyridine
Packaging
250mg
Price
$680
Updated
2021/12/16
Alichem
Product number
626619
Product name
4-Chloropyridine
Packaging
1g
Price
$1685
Updated
2021/12/16
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4-chloropyridine Chemical Properties,Usage,Production

Uses

4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMT's activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes [1].

Purification Methods

Pour 4-chloropyridine into distilled water, and excess of 6M NaOH is added to give pH 12. The organic phase is separated and extracted with four volumes of diethyl ether. The combined extracts are filtered through paper to remove water, and the solvent is evaporated. The dark brown residual liquid is kept under high vacuum [Vaidya & Mathias J Am Chem Soc 108 5514 1986]. It can be distilled, but readily darkens and is best kept as the hydrochloride [7379-35-3] M 150.1, m 163-165o(dec). [Beilstein 20/5 V 410.]

References

[1] Sen S, et al. Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase. ACS Chem Biol. 2019 Apr 19;14(4):613-618. DOI:10.1021/acschembio.9b00211

4-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloropyridine manufacturers

Dideu Industries Group Limited
Product
4-chloropyridine 626-61-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-06

626-61-9, 4-chloropyridineRelated Search:

2-[3-[Bis(2-chloroethyl)aMino]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one Trazodone-D6 Hydrochloride 2,6-Dichloropyridine Isotrazodone Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)- Trazodone Hydrochloride BP Impurity H DiHCl Trazodone 4-Hydroxytrazodone BIUREA 1-(4-Chlorophenyl)-4-(3-chloropropyl)piperazine 1-(3-Chlorophenyl)piperazine-d8 1-(3-Bromophenyl)piperazine MYRISTIC ACID DIETHANOLAMIDE 2,4-Dichloroaniline 3-Bromo-2-fluoropyridine 2,3,5-Collidine 6-BENZYL-5,7-DIOXO-OCTAHYDROPYRROLO[3,4-B] PYRIDINE 2-Hydroxy-4-methyl-5-nitropyridine

  • gamma-Chloropyridine
  • Pyridine, 4-chloro-
  • Trazodone Impurity 31
  • 4-chloropyridine ISO 9001：2015 REACH
  • 626-61-9