PipaMperone Dihydrochloride Property

Melting point:

203-218°C

storage temp. 

Hygroscopic, Refrigerator, Under Inert Atmosphere

solubility 

H2O: ~50mg/mL

form 

powder

color 

white

Water Solubility 

H2O: >2.0mg/mL

Stability:

Hygroscopic

Safety

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

1

RTECS 

DW1060000

Toxicity

mouse,LD50,intravenous,71mg/kg (71mg/kg),Drugs in Japan Vol. 6, Pg. 631, 1982.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

PipaMperone Dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Pipamperone dihydrochloride may be used:

• as an internal standard in liquid chromatography with coulometric detection
• as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
• as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Uses

Antipsychotic.

Definition

ChEBI: A hydrochloride resulting from the reaction of pipamperone with 2 mol eq. of hydrogen chloride. It is used as an antipsychotic.

Biochem/physiol Actions

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.