IA-14069

Product Name: IA-14069
CAS No.: 2271216-04-5
Chemical Name: IA-14069
Synonyms: IA-14069;tert-butyl 7-chloro-2-(2,5-difluorophenyl)-4-oxo-4H-chromene-3-carboxylate;4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo-, 1,1-dimethylethyl ester
CBNumber: CB39384722
Molecular Formula: C20H15ClF2O4
Formula Weight: 392.78
MOL File: 2271216-04-5.mol

More

Less

IA-14069 Property

Boiling point:: 487.0±45.0 °C(Predicted)
Density: 1.379±0.06 g/cm3(Predicted)
storage temp.: Store at -20℃
solubility: Soluble in DMSO
InChI: InChI=1S/C20H15ClF2O4/c1-20(2,3)27-19(25)16-17(24)12-6-4-10(21)8-15(12)26-18(16)13-9-11(22)5-7-14(13)23/h4-9H,1-3H3
InChIKey: FWIGHXSYEQALSL-UHFFFAOYSA-N
SMILES: C1(C2=CC(F)=CC=C2F)OC2=CC(Cl)=CC=C2C(=O)C=1C(OC(C)(C)C)=O

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

IA-14069 Chemical Properties,Usage,Production

Uses

IA-14069 is an orally active TNF-α inhibitor for studies related to rheumatoid arthritis.

Biological Activity

IA-14069 potently inhibits both TNF-α-induced cytotoxicity (IC50 < 0.7 μM), which directly binds to TNF-α and TNF-α-triggered signaling (p-IκBα and NF-κB p65) activities. The therapeutic and preventive anti-RA effects of IA-14069 were demonstrated in TNF-α-TG and CIA models. IA-14069 and MTX had synergistic effects in the CIA therapeutic model. According to pharmacokinetic analysis, IA-14069 showed significant bioavailability. In addition, no in vivo toxicity was observed even under treatment with an excessive amount of IA-14069[1].

References

[1] Sung-Dong Park. “THU0047 IA-14069, A NOVEL SMALL-MOLECULE INHIBITOR DIRECT-TARGETING TUMOR NECROSIS FACTOR-α, ATTENUATES COLLAGEN INDUCED ARTHRITIS.” Annals of the Rheumatic Diseases 78 1 (2019): 291–291.

IA-14069 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

IA-14069 Suppliers

China 9 Global 9

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5964
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4587
Advantage: 55

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1927
Advantage: 55

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Jinan Cen Ben Medical Technology Co., Ltd

Tel: 14793566
Email: info@cenpharm.com
Country: China
ProdList: 752
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9970
Advantage: 58

Wuhan Jingkang en Biomedical Technology Co., Ltd

Tel: +8613720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5221
Advantage: 58

2271216-04-5, IA-14069Related Search:

IA-14069

4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo-, 1,1-dimethylethyl ester

tert-butyl 7-chloro-2-(2,5-difluorophenyl)-4-oxo-4H-chromene-3-carboxylate

2271216-04-5