phenglutarimide hydrochloride
- Product Name
- phenglutarimide hydrochloride
- CAS No.
- 1674-96-0
- Chemical Name
- phenglutarimide hydrochloride
- Synonyms
- Einecs 216-819-3;Phenglutarimide HCl;Aturbane hydrochloride;phenglutarimide hydrochloride;racem. Phenglutarimid-hydrochlorid;Glutarimide, 2-(2-(diethylamino)ethyl)-2-phenyl-, hydrochloride;Chlorhydrate de alpha-phenyl-alpha-(beta'-diethylaminoethyl)glutarimide;Chlorhydrate de alpha-phenyl-alpha-(beta'-diethylaminoethyl)glutarimide [french]
- CBNumber
- CB3939640
- Molecular Formula
- C17H24N2O2.ClH
- Formula Weight
- 324.849
- MOL File
- 1674-96-0.mol
phenglutarimide hydrochloride Property
- Melting point:
- 168-172 °C (decomp)
- form
- Solid
Safety
- Toxicity
- LD50 orl-mus: 1200 mg/kg ARZNAD 15,534,65
N-Bromosuccinimide Price
- Product number
- API0025564
- Product name
- PHENGLUTARIMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.64
- Updated
- 2021/12/16
phenglutarimide hydrochloride Chemical Properties,Usage,Production
Originator
Ciba 10870, Ciba Pharmaceutical
Manufacturing Process
350 parts by weight of the potassium salt of 2-phenyl-2-(βdiethylaminoethyl)-pentane-1,5-diacid mononitrile are dissolved with heating in 700 parts by volume of glacial acetic acid, 850 parts by volume of acetic anhydride are added, and then 250 parts by volume of concentrated sulfuric acid introduced portionwise. The temperature of the reaction mixture in this operation rises to 120-130°C. When the reaction subsides, the whole is finally maintained for a further 15 min on the boiling water bath. The solvent is removed on the water bath under reduced pressure, the residue poured onto ice and caustic soda solution, and the whole extracted with chloroform. The chloroform solution washed with water, dried over potassium carbonate and the solvent evaporated. The crystalline residue, consisting of 3-phenyl-3-(βdiethylaminoethyl)-2,6-dioxopiperidine. After recrystallization from a mixture of ethyl acetate and ligroin, melts at 118-120°C.
The hydrochloride (produced by dissolving the base in ethyl acetate and adding an equivalent quantity of hydrochloric acid gas dissolved in ethylacetate) melts, after recrystallization from a mixture of methyl alcohol and ethyl acetate, at 168-172°C.
Therapeutic Function
Anticholinergic, Antiparkinsonian
Safety Profile
Moderately toxic by ingestion.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and HCl. Ananticholinergic and antispasmodic.
phenglutarimide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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