1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose

Product Name: 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose
CAS No.: 21740-23-8
Chemical Name: 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose
Synonyms: Chloro sugar;NSC 140594;5G/25G/1KG;Chloride sugar;Oxygen-2-deoxy-D-ribose;Trifluridine intermediate;chlorobenzoyl)-2-deoxy-D-ribose;3,5-O-bis(p-chlorobenzoyl)-2-deoxy-α-D-;1-Cl-3,5-bis-(4-cl-bz)- 2-deoxy-D-ribofuranose;1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose
CBNumber: CB3952869
Molecular Formula: C19H15Cl3O5
Formula Weight: 429.67
MOL File: 21740-23-8.mol

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1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose Property

Melting point:: 110-118°C (dec.)
Boiling point:: 530.6±50.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
Stability:: Not stable in Solution
InChI: InChI=1/C19H15Cl3O5/c20-13-5-1-11(2-6-13)18(23)25-10-16-15(9-17(22)26-16)27-19(24)12-3-7-14(21)8-4-12/h1-8,15-17H,9-10H2/t15-,16+,17-/s3
InChIKey: QEHCZULNFYDPPL-KIQRZSAINA-N
SMILES: C([C@H]1O[C@H](Cl)C[C@@H]1OC(C1C=CC(Cl)=CC=1)=O)OC(C1C=CC(Cl)=CC=1)=O |&1:1,3,6,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D432235
Product name: 3,5-Di-O-(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosylChloride
Packaging: 10g
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 1042AB
Product name: 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribofuranose
Packaging: 1g
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: 1042AB
Product name: 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribofuranose
Packaging: 5g
Price: $47
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MC145897
Product name: 1-Chloro-3,5-di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranose
Packaging: 10g
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: J97795
Product name: 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribofuranose
Packaging: 10g
Price: $65
Updated: 2021/12/16

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1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose Chemical Properties,Usage,Production

Chemical Properties

1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose is White Solid

Uses

Intermediate used in the synthesis of nucleotide analogs.Unstable in solution!

Uses

1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose is used in the synthesis of nucleotide analogs. Unstable in solution!

Synthesis

80339-59-9

21740-23-8

Example 3: Preparation of 1-[3,5-di-O-(p-chlorobenzoyl)]-2-deoxy-α-D-ribofuranosyl chloride To a 250 mL four-necked round-bottomed flask under nitrogen protection was added 1-O-methyl-3,5-di-O-(p-chlorobenzoyl)-2-deoxy-α/β-D-ribofuranose (15.94 g), glacial acetic acid (60 mL), anhydrous chloroform (30 mL), anhydrous dioxane (30 mL) and acetyl chloride (0.87 g). Under stirring conditions, gaseous HCl (11.5 g) was slowly passed while the reaction temperature was controlled between 13 and 15 °C. During this process, 1-[3,5-di-O-(p-chlorobenzoyl)]-2-deoxy-α-D-ribofuranosyl chloride was gradually crystallized and precipitated.After the completion of HCl passage, the reaction mixture was continued to be stirred at 12 °C for 20 min. Subsequently, the product was collected by filtration and washed with anhydrous hexane (20 mL). After drying, 12.4 g of the target compound 1-[3,5-di-O-(p-chlorobenzoyl)]-2-deoxy-α-D-ribofuranosyl chloride was obtained as a white powder in 77% yield.

References

[1] Patent: US2010/249394, 2010, A1. Location in patent: Page/Page column 4-5

1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose Suppliers

Canada 1 China 216 Germany 1 India 6 United Kingdom 2 United States 12 Global 238

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View Lastest Price from 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose 21740-23-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2023-01-06

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose 21740-23-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose 21740-23-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

21740-23-8, 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-riboseRelated Search:

2,3-O-Isopropylidene-D-ribofuranoside 1-ACETYL-2,3,5-TRI-O-BENZOYL-B-L-RIBOFURANOSE 1-O-Methyl-2-deoxy-D-ribose beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate (5-acetyloxy-3,4-dibenzoyloxy-oxolan-2-yl)methyl benzoate DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Difluorochloromethane 5-CHLOROPENTYL ACETATE 5-Chloropentyl benzoate 3-Chloropropyl acetate 2-Methoxyethoxymethyl chloride 2-Deoxy-D-ribose 1-CHLORO-3,5-DI-(P-CHLOROBENZOYL)-2-DEOXY-D-RIBOSE 1-CHLORO-3,5-DI-(P-CHLOROBENZOYL)-2-DEOXY-D-RIBOSE,88+% 2,3,5-TRI-O-BENZYL-L-ARABINOFURANOSE 1-(BENZYLOXY)-3-CHLOROPROPANE CHLORO 2,3,5-TRI-O-P-CHLOROBENZOYL-BETA-D-RIBOFURANOSIDE 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose

chlorobenzoyl)-2-deoxy-D-ribose

3,5-di-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl chloride

3,5-bis[o-(p-chlorbenzoyl)]-alpha-D-ribofuranosyl chloride

[(2S,3R,5R)-5-chloro-3-(4-chlorobenzoyl)oxyoxolan-2-yl]methyl 4-chlorobenzoate

3,5-O-Bis(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

1-Chloro-3,5-di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranose

1-a-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose

2-Deoxy-3,5-di-O-(4-chlorobenzoyl)-alpha-D-ribofuranosyl Chloride

Chloride sugar

Trifluridine intermediate

1-Cl-3,5-bis-(4-cl-bz)- 2-deoxy-D-ribofuranose

1-Chloro-3,5-bis-(4-chlorobenzoyl)-2-deoxy-D-ribofuranose

[5-Chloro-2-[(4-chlorobenzoyl)oxymethyl]oxolan-3-yl] 4-chlorobenzoate

1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose

(4S,5R)-2-chloro-4-benzoyloxy-5-(benzoyloxymethyl)tetrahydrofuran

1-α-Chloro-3,5-di-O-(4-chlorobenzoyl) -2-deoxy-D-ribofuranose

(2R,3S,4R,5R)-5-Chloro-2-((4-chlorobenzoyloxy)methyl)-4-hydroxytetrahydrofuran-3-yl 4-chlorobenzoate

3,5-Di-O-(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl Chloride

1-Chloro-2-deoxy-3,5-O-bis(p-chlorobenzoyl)-α-D-erythro-pentofuranose

3,5-Bis(4-chlorobenzoyl)-2-deoxy-.alpha.-D-ribofuranosyl Chloride

NSC 140594

5G/25G/1KG

3,5-O-Bis(p-chlorobenzoyl)-2-deoxy-alpha-D-ribofuranosyl chloride

a-D-erythro-Pentofuranosylchloride, 2-deoxy-, 3,5-bis(4-chlorobenzoate)

[(2R,3S,4R,5R)-5-chloro-3-[(4-chlorophenyl)carbonyloxy]-4-hydroxyoxolan-2-yl]Methyl 4-chlorobenzoate

(2S,3R,5R)-5-Chloro-2-(((4-chlorobenzoyl)oxy)-methyl)tetrahydrofuran-3-yl 4-chlorobenzoate

1-Chloro-2-deoxy-3,5-O-bis(4-chlorobenzoyl)-alpha-D-erythro-pentofuranose

(2R,3S,5R)-5-Chloro-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate

α-?D-?erythro-?Pentofuranosyl chloride, 2-?deoxy-?, 3,?5-?bis(4-?chlorobenzoate)

"3,5-Di-O-(p-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl Chloride"

Chloro sugar

3,5-O-bis(p-chlorobenzoyl)-2-deoxy-α-D-

2-deoxy-α-D-erythro-Pentofuranosyl chloride 3,5-bis(4-chlorobenzoate)

1-(3,5-di-O-(4-chlorobenzoyl) -2-deoxy-alpha-D-ribofuranosyl) chloride

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-ribofuranose

[5-chloro-3-(4-chlorobenzoyl)oxyoxolan-2-yl]methyl 4-chlorobenzoate

Oxygen-2-deoxy-D-ribose

3,5-Di-O-(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl Chloride

2-Deoxy-alpha-D-erythro-pentofuranosyl chloride 3,5-bis(4-chlorobenzoate)

21740-23-8

Bases & Related Reagents

Intermediates

Nucleotides