Hexamidine

Product Name: Hexamidine
CAS No.: 3811-75-4
Chemical Name: Hexamidine
Synonyms: Hexamidine;Hexamidine【antipeptic】;Hexcarbacholine bromide;4-[6-(4-amidinophenoxy)hexoxy]benzamidine;4,4'-(Hexamethylenedioxy)bis(benzamidine);4,4'-(Hexamethylenebisoxy)bis(benzamidine);4,4'-(1,6-Hexanediyl)bis(oxy)bisbenzamidine;4,4'-[1,6-Hexanediylbis(oxy)]bisbenzamidine;4,4'-[1,6-Hexanediylbis(oxy)]bis[benzamidine];Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)]bis-
CBNumber: CB3961315
Molecular Formula: C20H26N4O2
Formula Weight: 354.45
MOL File: 3811-75-4.mol

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Hexamidine Property

Boiling point:: 548.6±60.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
pka: 12.80±0.50(Predicted)
InChI: InChI=1S/C20H26N4O2/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24)
InChIKey: OQLKNTOKMBVBKV-UHFFFAOYSA-N
SMILES: C(OC1=CC=C(C(N)=N)C=C1)CCCCCOC1=CC=C(C(N)=N)C=C1
LogP: 3.000 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011612
Product name: HEXAMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $495.75
Updated: 2021/12/16

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Hexamidine Chemical Properties,Usage,Production

Description

Hexamidine (HEX) is a strong organic base and aromatic diamidine. Although hexamidine is primarily used as the diisethionate salt (HEX D), it was first synthesized as the dihydrochloride salt (HEX H) and patented for May & Baker Limited (U.K.) by Ewins et al. In the 1990s, the efficacy of HEX as an amoebicidal agent was demonstrated in several studies. In addition to biocidal activity, HEX, and other diamidines have demonstrated enzyme inhibition properties. Upregulation of the major cholesterol and fatty acid uptake pathways has also been demonstrated in a skin-equivalent tissue culture model following treatment with HEX[1].

Uses

hexamidine is generally used as a biocide and preservative. Some initial studies are indicating a potential to increase production of skin lipids, such as cholesterol, sphingolipids, and fatty acids. In turn this would help improve skin moisture content. Further evidence of this may be required.

Definition

ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.

Contact allergens

Hexamidine is an antiseptic active against Grampositive bacteria and fungi, used as a disinfectant and a preservative in cosmetics. It induces papulo-vesicular and diffuse allergic contact dermatitis.

References

[1] N. Parisi. “Hexamidine salts – applications in skin health and personal care products.” International Journal of Cosmetic Science 39 4 (2017): 361–365.

Hexamidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Hexamidine Suppliers

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View Lastest Price from Hexamidine manufacturers

Career Henan Chemical Co

Product: HEXAMIDINE 3811-75-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-24

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3811-75-4