2-Iodo-5-trifluoromethylpyridine
Application- Product Name
- 2-Iodo-5-trifluoromethylpyridine
- CAS No.
- 100366-75-4
- Chemical Name
- 2-Iodo-5-trifluoromethylpyridine
- Synonyms
- 2-Iodo-5-(Trifluoromethyl)Pyri;2-Iodo-5-trifluoromethylpyridine;5-(trifluoromethyl)-2-iodopyridine;2-Iodo-5-(trifluoromethyl)pyridine;Pyridine,2-iodo-5-(trifluoroMethyl)-;2-Iodo-5-(trifluoromethyl)pyridine 98%;6-Iodo-alpha,alpha,alpha-trifluoro-3-picoline;2-Iodo-5-trifluoromethylpyridine ISO 9001：2015 REACH
- CBNumber
- CB3967362
- Molecular Formula
- C6H3F3IN
- Formula Weight
- 272.99
- MOL File
- 100366-75-4.mol
2-Iodo-5-trifluoromethylpyridine Property
- Melting point:
- 82-83 °C(Solv: hexane (110-54-3))
- Boiling point:
- 215.7±40.0 °C(Predicted)
- Density
- 1.974±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- -0.58±0.10(Predicted)
- color
- Off-white
- Sensitive
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- ADE000407
- Product name
- 2-Iodo-5-trifluoromethyl-pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $497
- Updated
- 2025/07/31
- Product number
- I724828
- Product name
- 2-Iodo-5-(trifluoromethyl)pyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H32-K-X7
- Product name
- 2-Iodo-5-trifluoromethylpyridine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC9199
- Product name
- 2-Iodo-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- AK-24955
- Product name
- 2-Iodo-5-trifluoromethylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $36
- Updated
- 2021/12/16
2-Iodo-5-trifluoromethylpyridine Chemical Properties,Usage,Production
Application
5-Trifluoromethyl-2-iodopyridine is a pyridine compound. Due to the electron-deficient nature of the pyridine ring, the iodine atom in its structure can undergo deiodination under the attack of strong nucleophiles. It can also undergo cross-coupling reactions with aryl halides catalyzed by metallic copper. Furthermore, this substance can undergo deiodination cyanation with aryl iodine in the presence of copper cyano, and can be used in the synthesis of pyridine cyanides.
Synthesis
52334-81-3
75-36-5
100366-75-4
a) Synthesis of 2-iodo-5-trifluoromethylpyridine: Sodium iodide (43.3 g, 289.1 mmol) was added to a solution of 2-chloro-5-trifluoromethylpyridine (15.0 g, 82.6 mmol) in acetonitrile (400 mL), and the reaction mixture was stirred at 88 °C until the sodium iodide was completely dissolved. Subsequently, acetyl chloride (8.8 mL, 12.3 mmol) was slowly added dropwise to the solution and precipitation was observed. The reaction mixture was refluxed for 24 hours, cooled and concentrated to give an oil. The oil was dissolved in dichloromethane, washed sequentially with 10% sodium thiosulfate solution, 10% sodium carbonate solution and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by column chromatography using dichloromethane as eluent to give 10.9 g (48.4% yield) of light yellow target product.1H NMR (CDCl3): δ 8.68 (s, 1H), 7.88 (m, 1H), 7.49 (d, J = 9.9 Hz, 1H).
References
[1] Patent: US2003/45546, 2003, A1
2-Iodo-5-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Iodo-5-trifluoromethylpyridine manufacturers
- Product
- 2-Iodo-5-(trifluoromethyl)pyridine 100366-75-4
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-06-26
- Product
- 2-Iodo-5-trifluoromethylpyridine 100366-75-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
- Product
- 2-Iodo-5-trifluoromethylpyridine 100366-75-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 200kg
- Release date
- 2020-02-01