Colestipol HCl
- Product Name
- Colestipol HCl
- CAS No.
- 26658-42-4
- Chemical Name
- Colestipol HCl
- Synonyms
- tetraethylenepentamine/ epichlorohydrin copolymer;1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[( 2-aminoethyl)amino]ethyl]-, polymer with (chloromethyl)oxirane
- CBNumber
- CB3969902
- Molecular Formula
- C11H28ClN5O
- Formula Weight
- 281.83
- MOL File
- 26658-42-4.mol
Colestipol HCl Property
- LogP
- -2.480 (est)
- EPA Substance Registry System
- Tetraethylenepentamine epichlorohydrin polymer (26658-42-4)
Colestipol HCl Chemical Properties,Usage,Production
Originator
Colestid,Upjohn,US,1977
Uses
Antihyperlipidemic.
Manufacturing Process
Into a 1,000 gallon, jacketed, glass-lined reactor equipped with baffles and a two-speed (67 and 135 rpm) reversed impeller is introduced 200 g of Richonate 60B (a 60% aqueous slurry of sodium salts of alkylbenzenesulfonic acids) and 364 liters of deionized water, followed by 90.5 kg of tetraethylenepentamine rinsed in with 5 gallons of toluene. The solution is stirred at the low speed and then 500 gallons of toluene are added to form a dispersion. To the stirred dispersion is added 109 kg of epichlorohydrin, rinsed in with 5 gallons of toluene, and the resulting mixture is heated at reflux for two hours. The reaction mixture is cooled to about 20°C and then treated with 58.5 kg of a filtered 50% aqueous solution of sodium hydroxide. The mixture is removed from the reactor and filtered, and the copolymer is collected and dried by treating it first with hot (75°C to 80°C) filtered nitrogen and then with an 80°C air stream. The resulting crude product is returned to the reactor, washed extensively with filtered deionized water (at the low speed), dried with an 80°C air stream and blended until homogeneous to give about 155 kg of a dry tetraethylenepentamine-epichlorohydrin copolymer hydrochloride, particle diameter 0.002-0.02 inch.
brand name
Colestid (Pharmacia & Upjohn).
Therapeutic Function
Antihyperlipoproteinemic
Colestipol HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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