5-Methoxy-2-fluorobenzyl cyanide
- Product Name
- 5-Methoxy-2-fluorobenzyl cyanide
- CAS No.
- 672931-28-1
- Chemical Name
- 5-Methoxy-2-fluorobenzyl cyanide
- Synonyms
- 2-Fluoro-5-methoxybenzeneacetonitrile;2-Fluoro-5-methoxyphenylacetonitrile97%;Benzeneacetonitrile, 2-fluoro-5-methoxy-;2-Fluoro-5-methoxyphenylacetonitrile 97%;2-(2-fluoro-5-Methoxyphenyl)acetonitrile;Benzeneacetonitrile, 2-fluoro-5-methoxy- (9CI);2-Fluoro-5-methoxybenzyl cyanide, (2-Fluoro-5-methoxyphenyl)acetonitrile
- CBNumber
- CB3971792
- Molecular Formula
- C9H8FNO
- Formula Weight
- 165.16
- MOL File
- 672931-28-1.mol
5-Methoxy-2-fluorobenzyl cyanide Property
- Boiling point:
- 279℃
- Density
- 1.148
- Flash point:
- 122℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline powder
- color
- White
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M262713
- Product name
- 5-Methoxy-2-fluorobenzylcyanide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M262713
- Product name
- 5-Methoxy-2-fluorobenzylcyanide
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4637-3-98
- Product name
- 2-Fluoro-5-methoxyphenylacetonitrile
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 074679
- Product name
- 5-Methoxy-2-fluorobenzylcyanide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4637-3-98
- Product name
- 2-Fluoro-5-methoxyphenylacetonitrile
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
5-Methoxy-2-fluorobenzyl cyanide Chemical Properties,Usage,Production
Synthesis
773837-37-9
91319-42-5
672931-28-1
General procedure for the synthesis of 2-fluoro-5-methoxyphenylacetonitrile from the compound (CAS: 773837-37-9) and 2-fluoro-5-methoxybenzyl bromide: Sodium cyanide (362 mg, 7.53 mmol) was added to a solution of compound 4 (1.5 g, 6.84 mmol) in anhydrous ethanol (15 mL), and the reaction mixture was stirred for 2 hr at 85 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was concentrated to obtain the crude product. The crude product was diluted with ice water (30 mL) and extracted with ethyl acetate (2 x 50 mL). The organic layers were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by rapid chromatography on silica gel (eluent: petroleum ether/ethyl acetate, gradient gradually increased from 100/0 to 70/30) to afford compound 5 (1 g, 90% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6) δ: 7.21 (t, J = 9.2 Hz, 1H), 7.01 (dd, J = 6.1, 3.1 Hz, 1H), 6.94 (m, 1H), 4.01 (s, 2H), 3.75 (s, 3H). Mass spectrum (ESI) m/z: 166.06 [M+H]+.
References
[1] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 302-303
5-Methoxy-2-fluorobenzyl cyanide Preparation Products And Raw materials
Raw materials
Preparation Products
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