(2-OXO-IMIDAZOLIDIN-1-YL)-ACETIC ACID
- Product Name
- (2-OXO-IMIDAZOLIDIN-1-YL)-ACETIC ACID
- CAS No.
- 87219-22-5
- Chemical Name
- (2-OXO-IMIDAZOLIDIN-1-YL)-ACETIC ACID
- Synonyms
- 109340;2-(2-Oxoimidazolidin-1-yl);2-Oxo-1-imidazolidineacetic acid;2-Oxoimidazolidine-1-acetic Acid;1-Imidazolidineacetic acid, 2-oxo-;(2-oxo-imidazolidin-l-yl)-acetic acid;2-(2-oxoiMidazolidin-1-yl)acetic acid
- CBNumber
- CB41008973
- Molecular Formula
- C5H8N2O3
- Formula Weight
- 144.13
- MOL File
- 87219-22-5.mol
(2-OXO-IMIDAZOLIDIN-1-YL)-ACETIC ACID Property
- Boiling point:
- 487.1±24.0 °C(Predicted)
- Density
- 1.379
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.41±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- O991215
- Product name
- 2-(2-Oxoimidazolidin-1-yl)aceticacid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Z5232
- Product name
- 2-(2-Oxoimidazolidin-1-yl)aceticacid
- Packaging
- 250mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- 095804
- Product name
- 2-(2-Oxoimidazolidin-1-yl)acetic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $394
- Updated
- 2021/12/16
- Product number
- Z5232
- Product name
- 2-(2-Oxoimidazolidin-1-yl)aceticacid
- Packaging
- 1g
- Price
- $492
- Updated
- 2021/12/16
- Product number
- 095804
- Product name
- 2-(2-Oxoimidazolidin-1-yl)acetic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $874
- Updated
- 2021/12/16
(2-OXO-IMIDAZOLIDIN-1-YL)-ACETIC ACID Chemical Properties,Usage,Production
Synthesis
3699-54-5
87219-22-5
General procedure for the synthesis of (2-ketoimidazolyl)-acetic acid from 1-(2-hydroxyethyl)-2-imidazolidinone: 15% aqueous sodium bicarbonate (21 ml) was added to a solution of 1-(2-hydroxyethyl)-2-imidazolidinone (1.00 g, 7.68 mmol) in acetone (70 ml) to form a white slurry, which was subsequently cooled to 0°C (Refs. JOC 2003, 68, 4999-5001). Sodium bromide (0.16 g, 1.54 mmol) and TEMPO (0.024 g, 0.15 mmol) were added sequentially and the mixture was stirred for 10 min. Subsequently, trichloroisocyanuric acid (3.57 g, 15.4 mmol) was added in five equal portions, each five minutes apart. The light yellow slurry was warmed to 25°C and stirring was continued for 12 hours to obtain a yellow solution. Isopropanol (9 ml) was added and stirred for 45 minutes to form a white slurry which was filtered through diatomaceous earth. The filter cake was washed with an appropriate amount of solvent. The filtrate was concentrated under reduced pressure, neutralized with saturated aqueous sodium bicarbonate and extracted with ethyl acetate (50 ml). The aqueous phase was adjusted to pH ≈ 2 with 4N HCl and then extracted continuously with a 5% methanol/dichloromethane solvent mixture (~120 ml) for 16 hours. The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give (2-oxoimidazolidin-1-yl)acetic acid (0.530 g, 48% yield) as a white solid.
References
[1] Patent: WO2006/138350, 2006, A2. Location in patent: Page/Page column 87-88
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