DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE

Product Name: DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE
CAS No.: 106961-33-5
Chemical Name: DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE
Synonyms: SKL407;Zolpidem Impurity 67;imidazo[1,2-a]pyridin-3-yl);N,N-Dimethyl-1-(6-methyl-2-(p-tolyl);DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE;Imidazo[1,2-a]pyridine-3-methanamine, N,N,6-trimethyl-2-(4-methylphenyl)-;3-(DiMethylaMinoMethyl)-6-Methyl-2-(4-Methylphenyl)iMidazo[1,2-a]pyridine;N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
CBNumber: CB41011199
Molecular Formula: C18H21N3
Formula Weight: 279.38
MOL File: 106961-33-5.mol

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DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Property

Melting point:: 134 - 139°C
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 8.30±0.28(Predicted)
form: Solid
color: White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D461105
Product name: 3-(Dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
Packaging: 50mg
Price: $185
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026359
Product name: 3-(DIMETHYLAMINOMETHYL)-6-METHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $500.95
Updated: 2021/12/16

Ambeed

Product number: A180483
Product name: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
Purity: 97%
Packaging: 1g
Price: $548
Updated: 2021/12/16

Crysdot

Product number: CD11356956
Product name: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
Purity: 97%
Packaging: 5g
Price: $945
Updated: 2021/12/16

Chemenu

Product number: CM247603
Product name: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
Purity: 97%
Packaging: 5g
Price: $1206
Updated: 2021/12/16

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DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Chemical Properties,Usage,Production

Synthesis

50-00-0

88965-00-8

124-40-3

106961-33-5

Step (i): Preparation of N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methylamine (8). Under stirring, 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine (200 g, 0.92 mol) was dissolved in acetic acid (985 mL). The reaction mixture was cooled to 0-5 °C and 40% aqueous dimethylamine (157 g, 1.39 mol) was slowly added followed by paraformaldehyde (36.11 g, 1.20 mol). The reaction mixture was stirred at 50-55°C for 3-4 hours, followed by removal of acetic acid under reduced pressure. Water (1.5 l) was added, the filtrate was filtered through a diatomaceous earth pad and the filtrate was alkalized to pH 8.0-8.5 by dropwise addition of 30% sodium hydroxide solution. filtration afforded an off-white solid, which was washed sequentially with water (500 ml) and hexane (200 ml). The solid was dried to constant weight in an oven to give 230 g of N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methylamine (8) in 91.6% yield and 93.5% purity. Melting point range: 137.9-141.5 °C. IR spectrum (cm^-1): 2944, 2809, 2761, 1502, 1454, 1389, 1018, 829, 799. 1H NMR (400 MHz, CDCl3): δ 2.25 (s, 6H), 2.36 (s, 3H), 2.40 (s, 3H), 3.84 (s, 2H), 7.04 (dd, J = 9.1 Hz, J = 1.6 Hz, 1H), 7.25 (d, J = 7.9 Hz, 2H), 7.52 (d, J = 9.1 Hz, 1H), 7.69 (d, J = 8.0 Hz, 2H), 8.10 (s, 1H). Mass spectrum (m/z): 280.4 (M + H)+.

References

[1] Patent: WO2009/7995, 2009, A1. Location in patent: Page/Page column 11; 13-14; 15-17
[2] Farmaco, 1991, vol. 46, # SUPPL. 1, p. 277 - 288
[3] Acta Poloniae Pharmaceutica - Drug Research, 2001, vol. 58, # 1, p. 43 - 52
[4] Patent: US2007/27180, 2007, A1. Location in patent: Page/Page column title page; sheet 1; 6

DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE Suppliers

Canada 1 China 24 India 3 United States 4 Global 32

J & K SCIENTIFIC LTD.

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106961-33-5, DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINERelated Search:

TERT-BUTYL DIAZOACETATE Zolpidem Impurity 64 Zolpidem-d6 Phenyl-4-carboxylic Acid Zolpidem 6-Carboxylic Acid Methyl Ester Zolpidem Phenyl-4-carboxylic Acid Ethyl Ester-d6 2-[4-(Ethoxycarbonyl)phenyl]-6-methyl-imidazo[1,2-a]pyridine Zolpidem Phenyl-4-carboxylic Acid 6-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic Acid, Zolpidem 6-Carboxylic Acid 4-methyl-N-[3,4,6-trideuterio-5-(trideuteriomethyl)pyridin-2-yl]benzamide Zolpidem Impurity 18 Zolpidem Phenyl-4-carboxylic Acid Ethyl Ester 6-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-a]pyridine 6-Methyl-2-(4-Methylphenyl)-α-oxo-iMidazo[1,2-a]pyridine-3-acetic Acid Ethyl Ester Zolpidem-d6 6-Carboxylic Acid 2-[4-(Ethoxycarbonyl)phenyl]-6-methyl-imidazo[1,2-a]pyridine-3-acetic Acid N,N-dimethyl-2-oxo-2-[5,7,8-trideuterio-2-(4-methylphenyl)-6-(trideuteriomethyl)imidazo[1,2-a]pyridin-3-yl]acetamide Zolpidem-d6 6-Carboxylic Acid Methyl Ester

DIMETHYL-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YLMETHYL)-AMINE

3-(DiMethylaMinoMethyl)-6-Methyl-2-(4-Methylphenyl)iMidazo[1,2-a]pyridine

N,N-dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine

imidazo[1,2-a]pyridin-3-yl)

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)

Imidazo[1,2-a]pyridine-3-methanamine, N,N,6-trimethyl-2-(4-methylphenyl)-

Zolpidem Impurity 67

SKL407

106961-33-5

Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals