ChemicalBook > CAS DataBase List > Minodronic acid

Minodronic acid

Product Name
Minodronic acid
CAS No.
180064-38-4
Chemical Name
Minodronic acid
Synonyms
BPH 261;Bonoteo;Recalbon;ONO 5920;Nsc725590;Minodronicaci;Mino phosphate;Minodronic Acid;Minodronic acid (anhydrous);(127657-42-5) minodronic acid
CBNumber
CB41011573
Molecular Formula
C9H12N2O7P2
Formula Weight
322.15
MOL File
180064-38-4.mol
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Minodronic acid Property

Density 
1.97±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Aqueous Base (Slightly), Methanol (Slightly)
form 
Solid
pka
1.48±0.10(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M344900
Product name
MinodronicAcid
Packaging
10mg
Price
$80
Updated
2021/12/16
TRC
Product number
M344900
Product name
MinodronicAcid
Packaging
250mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0006290
Product name
Minodronicacid
Purity
>98.0%
Packaging
10mg
Price
$50
Updated
2021/12/16
Ark Pharm
Product number
AK119862
Product name
(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonicacid
Purity
95+%
Packaging
250mg
Price
$84
Updated
2021/12/16
Matrix Scientific
Product number
100293
Product name
(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid
Purity
95+%
Packaging
250mg
Price
$147
Updated
2021/12/16
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Minodronic acid Chemical Properties,Usage,Production

Description

Minodronic acid hydrate, a third-generation bisphosphonate, was approved and launched in Japan for the oral treatment of osteoporosis. Osteoporosis is a skeletal disorder characterized by low bone mass and structural deterioration of bone tissue resulting in bone fragility and increased susceptibility to fractures, particularly of the hip, spine, and wrist. It is the most common type of metabolic bone disease and a major health concern affecting 200 million women worldwide. Minodronic acid is the newest nitrogen-containing bisphosphonate to reach the market. In vitro, it inhibits recombinant human FPP synthase activity with similar potency as zoledronic acid (IC50 = 3 nM for both agents).
The most common adverse events associated with minodronic acid included stomach and abdominal discomfort, abdominal pain, decrease in blood calcium level, and gastritis. The chemical synthesis of minodronic acid starts with a condensation reaction of 2-aminopyridine with ethyl 4-bromo-3-oxobutyrate by means of sodium bicarbonate to produce 2-(imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester, which is hydrolyzed to the corresponding carboxylic acid with potassium hydroxide. Treatment of the carboxylic acid intermediate with phosphorus acid and phosphorus trichloride followed by hydrolysis with hydrochloric acid gives minodronic acid.

Originator

Astellas Pharma (Japan)

Uses

Minodronic acid is developed for osteoporosis treatment.

brand name

Recalbon, Bonoteo

Minodronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Minodronic acid Suppliers

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View Lastest Price from Minodronic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Minodronic acid 180064-38-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06
Hebei Weibang Biotechnology Co., Ltd
Product
Minodronic acid 180064-38-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Henan Bao Enluo International TradeCo.，LTD
Product
Minodronic acid 180064-38-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-08-15

180064-38-4, Minodronic acidRelated Search:

Imidazolidinyl urea Imidazole Levamisole Thiabendazole alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Acyclovir Calcium dobesilate Imidazo[1,2-a]pyridine

  • PHOSPHONIC ACID, (1-HYDROXY-2-IMIDAZO(1,2-A)PYRIDIN-3-YLETHYLIDENE)BIS-
  • 1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-bis(phosphonic acid)
  • (127657-42-5) minodronic acid
  • 1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)-1,1-ethanediyl]bis(phosphonic acid)
  • (1-Hydroxy-2-imidazo[1,2-A]pyridin-3-yl-1-ethyl)-1,1-bisphos phonate
  • Nsc725590
  • Bonoteo
  • BPH 261
  • ONO 5920
  • Recalbon
  • (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid
  • Phosphonic acid,P,P'-(1-hydroxy-2-iMidazo[1,2-a]pyridin-3-ylethylidene)bis-
  • Minodronic acid (anhydrous)
  • Minodronicaci
  • PHOSPHONIC ACID, (1-HYDROXY-2-IMIDAZO(1,2-A)PYRIDIN-3-YLETHYLIDENE)BIS- ISO 9001：2015 REACH
  • Minodronic Acid
  • Mino phosphate
  • Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-|||ONO-5920|||YM-529
  • 180064-38-4
  • C9H12N2O7P2
  • API