Ethanone,1-(6-fluoro-2-pyridinyl)-

Product Name: Ethanone,1-(6-fluoro-2-pyridinyl)-
CAS No.: 501009-05-8
Chemical Name: Ethanone,1-(6-fluoro-2-pyridinyl)-
Synonyms: 1-(6-Fluoropyridin-2-yl);1-(6-Fluoro-2-pyridyl)ethanone;1-(6-fluoro-2-pyridinyl)-Ethanone;Ethanone,1-(6-fluoro-2-pyridinyl)-;Ethanone, 1-(6-fluoro-2-pyridinyl)- (9CI)
CBNumber: CB41012444
Molecular Formula: C7H6FNO
Formula Weight: 139.13
MOL File: 501009-05-8.mol

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Ethanone,1-(6-fluoro-2-pyridinyl)- Property

Boiling point:: 211.0±20.0 °C(Predicted)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.08±0.10(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 6832AB
Product name: 1-(6-Fluoropyridin-2-yl)ethanone
Packaging: 100mg
Price: $181
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0064959
Product name: 1-(6-FLUOROPYRIDIN-2-YL)ETHANONE
Purity: 95.00%
Packaging: 5MG
Price: $502.7
Updated: 2021/12/16

Alichem

Product number: 501009058
Product name: 1-(6-Fluoropyridin-2-yl)ethanone
Packaging: 250mg
Price: $160.68
Updated: 2021/12/16

Chemenu

Product number: CM123015
Product name: 1-(6-fluoropyridin-2-yl)ethan-1-one
Purity: 98%
Packaging: 1g
Price: $365
Updated: 2021/12/16

Crysdot

Product number: CD11115489
Product name: 1-(6-Fluoropyridin-2-yl)ethanone
Purity: 98%
Packaging: 1g
Price: $386
Updated: 2021/12/16

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Ethanone,1-(6-fluoro-2-pyridinyl)- Chemical Properties,Usage,Production

Synthesis

676343-47-8

676-58-4

501009-05-8

Step B-1: Synthesis of 1-(6-fluoropyridin-2-yl)ethanone 1. dissolve 6-fluoro-N-methyl-N-(methoxy)-2-pyridinecarboxamide (1.10 g, 5.97 mmol) in 40 mL of anhydrous THF under stirring conditions and cool the solution to 0°C. 2. add methylmagnesium chloride (8.0 mL, 3.0 M in THF) via a syringe. 2. Methylmagnesium chloride (8.0 mL, 3.0 M solution in THF, 24 mmol) was added slowly via syringe, keeping the reaction temperature at 0°C. 3. The reaction mixture was stirred at 0°C for 30 min. 4. The reaction was burst by the addition of saturated ammonium chloride solution (20 mL). 5. Pour the reaction mixture into a separatory funnel, add water (20 mL) and ether (30 mL), shake well and leave to stratify. 6. Separate the organic layer and extract the aqueous layer with ether (2 × 20 mL). 7. Combine all organic layers and wash with saturated brine (20 mL). 8. The organic layer was dried with anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the crude product. 9. The crude product was purified by column chromatography to afford 1-(6-fluoropyridin-2-yl)ethanone (0.746 g, 90% yield). 10. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 8.24 (m, 1H), 7.94 (ddd, J = 7.4, 2.5, 0.7 Hz, 1H), 7.54 (dd, J = 8.2, 2.7, 0.7 Hz, 1H), 2.62 (s, 3H).

References

[1] Patent: US2008/300247, 2008, A1. Location in patent: Page/Page column 120
[2] Patent: WO2007/143456, 2007, A2. Location in patent: Page/Page column 261

Ethanone,1-(6-fluoro-2-pyridinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethanone,1-(6-fluoro-2-pyridinyl)- Suppliers

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PYRIDINE

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