Dianhydrogalactitol

ChemicalBook > CAS DataBase List > Dianhydrogalactitol

Product Name: Dianhydrogalactitol
CAS No.: 23261-20-3
Chemical Name: Dianhydrogalactitol
Synonyms: 1,2:5,6-Dianhydrogalactitol;VAL-083;VAL083;VAL 083;NSC-132313;Dulcitol diepoxide;Dianhydrodulcitolum;Dianhydrogalactitol;5,6-Diepoxydulcitol;1,2:5,6-Diepoxydulcitol
CBNumber: CB41016710
Molecular Formula: C6H10O4
Formula Weight: 146.14
MOL File: 23261-20-3.mol

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Dianhydrogalactitol Property

Melting point:: 96.5-98.5 °C
Boiling point:: 185.74°C (rough estimate)
Density: 1.567
refractive index: 1.4310 (estimate)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 13.53±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3333
Product name: Dianhydrogalactitol
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $88.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3333
Product name: Dianhydrogalactitol
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $357
Updated: 2024/03/01

TRC

Product number: D720515
Product name: DulcitolDiepoxide
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 293253
Product name: 1,2:5,6-Dianhydrogalactitol
Packaging: 100mg
Price: $602
Updated: 2021/12/16

ChemScene

Product number: CS-1358
Product name: VAL-083
Packaging: 5mg
Price: $220
Updated: 2021/12/16

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Dianhydrogalactitol Chemical Properties,Usage,Production

Uses

Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.

Biological Activity

val-083 is a bi-functional alkylating agent, with potential antitumor activity.val-083 can cross the blood brain barrier and appears to be selective for tumor cells. val-083 alkylates and crosslinks dna which ultimately inhibit the proliferation of cancer cells. val-083 does not show cross-resistance to other conventional chemotherapeutic agents. the half-life of val-083 in the brain is long. val-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.

in vitro

VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h.

in vivo

VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. It (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.

target

DNA

References

http://www. delmarpharma.com/product_development_programs/val083/

Dianhydrogalactitol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dianhydrogalactitol manufacturers

Dideu Industries Group Limited

Product: Dianhydrodulcitol
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-05

23261-20-3, Dianhydrogalactitol Related Search:

6-DEOXY-L-GALACTITOL Dulcitol

Dianhydrogalactitol

Dianhydrodulcitolum

1,2,5,6-DIANHYDRODULCITOL

1,2:5,6-Diepoxyhexane-3,4-diol

1,2-Di(oxiranyl)ethylene glycol

Dulcitol diepoxide

NSC-132313

1,2:5,6-Dianhydrogalactitol

1,2:5,6-Diepoxydulcitol

5,6-Diepoxydulcitol

VAL 083

VAL083

VAL-083

VAL083; VAL083; VAL083; DIANHYDRODULCITOL; DIANHYDROGALACTITOL; DULCITOL DIEPOXIDE;

Galactitol, 1,2:5,6-dianhydro-

Dianhydrodulcitol USP/EP/BP

VAL-083，Dianhydrodulcitol

VAL-083,Inhibitor,DNA Alkylator/Crosslinker,VAL 083,inhibit,VAL083

23261-20-3

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