ChemicalBook > CAS DataBase List > Propofol

Propofol

Product Name
Propofol
CAS No.
2078-54-8
Chemical Name
Propofol
Synonyms
2,6-DIISOPROPYLPHENOL;DIPRIVAN;Propofol USP;Anepol;Ivofol;PD18215;AMpofol;Aquafol;Recofol;Dipravan
CBNumber
CB4101882
Molecular Formula
C12H18O
Formula Weight
178.27
MOL File
2078-54-8.mol
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Propofol Property

Melting point:
18 °C (lit.)
Boiling point:
256 °C/764 mmHg (lit.)
Density 
0.962 g/mL at 25 °C (lit.)
vapor pressure 
5.6 mm Hg ( 100 °C)
refractive index 
n20/D 1.514(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, miscible with hexane and with methanol
pka
pKa 11.10(H2O,t =20)(Approximate)
form 
<18°C Solid,>18°C Liquid
color 
Pale Yellow to Yellow
Odor
at 100.00?%. mild phenolic
Water Solubility 
Very slightly soluble in water.
Merck 
14,7834
BRN 
1866484
InChIKey
OLBCVFGFOZPWHH-UHFFFAOYSA-N
LogP
3.790
CAS DataBase Reference
2078-54-8(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2,6-bis(1-methylethyl)-(2078-54-8)
EPA Substance Registry System
2,6-Diisopropylphenol (2078-54-8)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements 
26-36/37/39-37/39-36-45-36/37-16-7
RIDADR 
2810
WGK Germany 
3
RTECS 
SL0810000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29089990
Hazardous Substances Data
2078-54-8(Hazardous Substances Data)
Toxicity
dog,LD50,intravenous,30mg/kg (30mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1117, 1996.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D126608
Product name
2,6-Diisopropylphenol
Purity
97%
Packaging
5g
Price
$39.1
Updated
2024/03/01
Sigma-Aldrich
Product number
P-076
Product name
Propofol solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$146
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1031
Product name
Propofol
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
1ML
Price
$269
Updated
2024/03/01
Sigma-Aldrich
Product number
56931
Product name
2,6-Diisopropylphenol
Purity
analytical standard
Packaging
1ml
Price
$73.5
Updated
2022/05/15
Alfa Aesar
Product number
L06841
Product name
2,6-Diisopropylphenol, 97%
Packaging
25g
Price
$31.3
Updated
2024/03/01
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Propofol Chemical Properties,Usage,Production

Description

Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.

Chemical Properties

Light Yellow Liquid

Originator

ICI (United Kingdom)

Uses

A anesthetic used in veterinary medicine

Uses

Propofol is an anesthetic used in veterinary medicine.

Uses

2,6-DIPP is the active ingredient for intravenous anesthetic formulations, also has applications as an intermediate for polymers

Definition

ChEBI: Propofol is a phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group. It has a role as an intravenous anaesthetic, a sedative, a radical scavenger, an antiemetic and an anticonvulsant.

brand name

Diprivan (Abraxis);Disoprivan;Disprofol;Rapinovet.

World Health Organization (WHO)

Propofol, a short acting injectable anaesthetic, was introduced in 1987. In April 1992, the Norwegian Medicines Control Board reported that prolonged use of propofol had been associated with two fatalities in children characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The UK Committee on the Safety of Medicines has received 5 reports of deaths occurring in children who had received propofol while in intensive care.

Biological Functions

Propofol (Diprivan) is rapidly acting, has a short recovery time, and possesses antiemetic properties. A rapid onset of anesthesia (50 seconds) is achieved, and if no other drug is administered, recovery will take place in 4 to 8 minutes.The recovery is attributed to redistribution of the drug and rapid metabolism to glucuronide and sulfate conjugates by the liver and extrahepatic tissues, such as intestine and kidney.
Rapid recovery and its antiemetic properties make propofol anesthesia very popular as an induction agent for outpatient anesthesia. Propofol can also be used to supplement inhalational anesthesia in longer procedures. Both continuous infusion of propofol for conscious sedation and with opioids for the maintenance of anesthesia for cardiac surgery are acceptable techniques.

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 712, 1956 DOI: 10.1021/jo01112a621

General Description

Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.

Biological Activity

Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.

Pharmacology

Propofol is primarily a hypnotic drug with substantial cardiorespiratory depressant actions and with no ability to produce neuromuscular blockade. While propofol lacks analgesic properties, its use permits lower doses of opioids. Likewise, less propofol is required for adequate hypnosis when it is administered with opioids.Thus, it is said that propofol and opioids interact synergistically.

Clinical Use

Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.

Side effects

The dose of propofol should be reduced in older patients; however, it does have a relatively linear dose– response characteristic, and patients generally can be safely titrated. The pain on injection, especially when small veins are used, can be considerably reduced if lidocaine 20 mg is administered first.
Anesthesia induction with propofol causes a significant reduction in blood pressure that is proportional to the severity of cardiovascular disease or the volume status of the patient, or both. However, even in healthy patients a significant reduction in systolic and mean arterial blood pressure occurs. The reduction in pressure appears to be associated with vasodilation and myocardial depression. Although propofol decreases systemic vascular resistance, reflex tachycardia is not observed. This is in contrast to the actions of thiopental. The heart rate stabilization produced by propofol relative to other agents is likely the result of either resetting or inhibiting the baroreflex, thus reducing the tachycardic response to hypotension.
Since propofol does not depress the hemodynamic response to laryngoscopy and intubation, its use may permit wide swings in blood pressure at the time of induction of anesthesia. Propofol should be used with utmost caution in patients with cardiac disease.

Safety Profile

Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also PHENOL

Veterinary Drugs and Treatments

In appropriate patients, propofol may be useful as an induction agent (especially before endotracheal intubation or an inhalant anesthetic), and as an anesthetic for outpatient diagnostic or minor procedures (e.g., laceration repair, radiologic procedures, minor dentistry, minor biopsies, endoscopy, etc.).
Propofol is used as a treatment for refractory status epilepticus, as it tends to cause less cardiovascular depression and recoveries can be smoother than with pentobarbital. Propofol may be of particular usefulness for use in Greyhounds and in patients with preexisting cardiac dysrhythmias. At low dosages, propofol is being investigated as an appetite stimulant in dogs.
Propofol may be safely used in animals with liver or renal disease and mild to moderate cardiac disease.
In dogs, propofol’s labeled indications are: 1) for induction of anesthesia; 2) for maintenance of anesthesia for up to 20 minutes; 3) for induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Propofol Preparation Products And Raw materials

Raw materials

Cationic resin Isobutylene Triphenylantimony Diisopropyl ether

Preparation Products

2-Isopropylphenol
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View Lastest Price from Propofol manufacturers

Dorne Chemical Technology co. LTD
Product
Propofol 2078-54-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 ton
Release date
2024-03-26
Jinan Million Pharmaceutical Co., Ltd
Product
Propofol 2078-54-8
Price
US $1.00/kg
Min. Order
0.10000000kg
Purity
99%
Supply Ability
200KG
Release date
2024-10-18
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Propofol 2078-54-8
Price
US $999.00-666.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-14

2078-54-8, PropofolRelated Search:

2,6-Dimethylphenol DIISOPROPYLBENZENE Diethyl isopropylmalonate DIISOPROPYL ZINC 1.0M SOLUTION IN TOLU& Lithium diisopropylamide N-Methyl-2-pyrrolidone Diisopropylamine 2,6-DIISOPROPYLNAPHTHALENE N,N'-Diisopropylcarbodiimide 2-Isopropylphenol N,N'-DIISOPROPYLTHIOUREA N,N-Diisopropylethylamine 4,4'-Bi(2,6-diisopropylphenol) 2,4-DIISOPROPYLPHENOL PROPOFOL RELATED COMPOUND C (50 MG) (2,6-DIISOPROPYLPHENYL ISOPROPYLETHER) 2,5-DIISOPROPYLPHENOL 4-Isopropylphenol 2,6-Diisopropyl-1,4-benzoquinone

  • 2,6-DIISOPROPYLPHENOL
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  • Diprivan10
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  • Phenol, 2,6-diisopropyl-
  • Phenol,2,6-bis(1-methylethyl)-
  • Phenol,2,6-diisopropyl-
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  • DISOPRIVAN
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  • ICI-35868
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  • Diprifusor
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  • 2,6-diisopropyl-pheno
  • 2 6-DIISOPROPYLPHENOL 97+%
  • PROPOFOL(2,6-DIISOPROPYLPHENOL)
  • 2,6-Diisopropylphenol, tech., 90%
  • 2,6-Bis(1-methylethyl)phenol, ICI-35868, Disoprivan, Rapinovet
  • 2,6-Diisopropyl
  • 2,6-DIISOPROPYLPHENOL / PROPOFOL
  • 2,6-DIISOPROPYLPHENOL 98+%
  • 2,6-Diisopropylphenol, 99% 5GR
  • 2,6-Bis(Isopropyl)-phenol, Dipravan, Propofol
  • Disopfivan
  • Diprofol
  • Recofol
  • 2,6-Diisopropylphenol ,99%
  • Dipriban
  • 2,6-Diisopropylphenol,90%,tech.
  • ICI 35868, Dipravan
  • 2,6-Diisopropylphenol,2,6-Bis(isopropyl)phenol, Propofol
  • Propofol (200 mg)
  • 2,6-bis(propan-2-yl)phenol
  • Propofol for peak identification CRS
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  • 2078-54-8