ChemicalBook > CAS DataBase List > 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

Product Name
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
CAS No.
161187-57-1
Chemical Name
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
Synonyms
αGlucosidaseIN23;α-Glucosidase-IN-23;α-Glucosidase-IN-23, 10 mM in DMSO;3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
CBNumber
CB410220715
Molecular Formula
C20H23NO6
Formula Weight
373.4
MOL File
161187-57-1.mol
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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Property

Boiling point:
481.5±45.0 °C(Predicted)
Density 
1.225±0.06 g/cm3(Predicted)
pka
3.06±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Chemical Properties,Usage,Production

Uses

α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].

in vivo

α-Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits a-glucosidase in mice[1].

Animal Model:Mice[1]
Dosage:0.2 mmol/kg
Administration:Oral; 0.2 mmol/kg/day
Result:
Cmax (nmol/mL)Tmax (h)T1/2(h)AUC (ng/h/mL)
10.11 ± 1.170.8 ± 0.01.90 ± 1.0436.7 ± 2.23

References

[1] Peter A Sidhom, et al. Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species. J Med Chem. 2023 Jan 12;66(1):991-1010. DOI:10.1021/acs.jmedchem.2c01818

3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Suppliers

China 5 United States 1 Global 6
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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TargetMol Chemicals Inc.
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15002134094
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Sangon Biotech (Shanghai) Co.,Ltd.
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Proteintech China
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161187-57-1, 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl esterRelated Search:

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  • 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
  • αGlucosidaseIN23
  • α-Glucosidase-IN-23
  • α-Glucosidase-IN-23, 10 mM in DMSO
  • 161187-57-1