Voriconazole

Product Name: Voriconazole
CAS No.: 137234-71-0
Chemical Name: Voriconazole
Synonyms: Voriconazole(Non-GMP);Voriconazole 9,11-epoxide;AMYMCJHOGKVJHB-CRFUWKMFSA-N;Voriconazole camphor sulfonate;(2R, 3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidine-4yl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol camphor sulfonate;(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate;(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-camphorsulfonate;(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate;(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate(for Voriconazole);(2 r, 3 s) - 2 - (2, 4-2 fluorinated phenyl) - 3 - (5 - fluorine pyrimidine - 4 -) - 1 - (1 h - 1, 4-trichlorobenzene triazole - 1 - base) - 2 - butanol sinistral camphor sulfonate
CBNumber: CB41026157
Molecular Formula: C26H30F3N5O5S
Formula Weight: 581.61
MOL File: 137234-71-0.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CCH0031477
Product name: (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL L-(-)-10-CAMPHORSULFONATE
Purity: 95.00%
Packaging: 5MG
Price: $501.35
Updated: 2021/12/16

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Voriconazole Chemical Properties,Usage,Production

Uses

Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

in vivo

Voriconazole (5-20 mg/kg; p.o. for 21 days) camphorsulfonate prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) camphorsulfonate decreases the fungal burden in the lungs^[3].

Animal Model:	Male specific-pathogen-free BALB/cByJ mice^[3]
Dosage:	1, 5, 20 mg/kg/day
Administration:	P.o. once daily for 21 days
Result:	Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.

References

[1] Nickie D Greer. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8. DOI:10.1080/08998280.2003.11927910
[2] Lesley J Scott, et al. Voriconazole : a review of its use in the management of invasive fungal infections.Drugs. 2007;67(2):269-98. DOI:10.2165/00003495-200767020-00009
[3] A M Sugar,et al. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob Agents Chemother. 2001 Feb;45(2):601-4. DOI:10.1128/AAC.45.2.601-604.2001

Voriconazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Voriconazole Suppliers

China 41 Europe 2 India 3 United States 2 Global 48

Beijing Lianben Pharm-Chemicals Tech. Co., Ltd

Tel: +86-10-83386766
Fax: +86-10-83386758
Email: sales@lianben.com
Country: China
ProdList: 91
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4942
Advantage: 58

Hangzhou Dingyan Chem Co., LTD

Tel: 0571-87157530-8007 13868066926
Fax: 0571-87156470
Email: sales@dingyanchem.com
Country: China
ProdList: 2616
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003 18601689453;
Email: info@qiaochem.com
Country: China
ProdList: 6060
Advantage: 65

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10028
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29640
Advantage: 60

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Jinan Ruisi Pharmaceutical Technology Co., LTD

Tel: 0531-0531-69900633 19963472814
Email: changyuan20@163.com
Country: China
ProdList: 4869
Advantage: 58

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View Lastest Price from Voriconazole manufacturers

Career Henan Chemical Co

Product: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate 137234-71-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

137234-71-0, VoriconazoleRelated Search:

[2H3]- Voriconazole N-Oxide Voriconazole Impurity 18 Voriconazole (2R,3R)-Isomer Voriconazole Impurity 8 Voriconazole Voriconazole Impurity 53 Voriconazole Related CoMpound C Voriconazole-13C3 rac 5-Desfluoro Voriconazole Voriconazole Vfend

(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate

(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate(for Voriconazole)

4-PyriMidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-, (αR,βS)-, Mono[(1R,4S)-7,7-diMethyl-2-oxobicyclo[2.2.1]heptane-1-Methanesulfonate] (salt)

Voriconazole camphor sulfonate

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate

AMYMCJHOGKVJHB-CRFUWKMFSA-N

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-camphorsulfonate

(2R, 3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidine-4yl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol camphor sulfonate

(2 r, 3 s) - 2 - (2, 4-2 fluorinated phenyl) - 3 - (5 - fluorine pyrimidine - 4 -) - 1 - (1 h - 1, 4-trichlorobenzene triazole - 1 - base) - 2 - butanol sinistral camphor sulfonate

Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1R,4S)-, compd. with (αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (1:1)

Voriconazole 9,11-epoxide

Voriconazole(Non-GMP)

137234-71-0

C16H14F3N5OC10H16O4S

intermediate