3-PyridineCarboxamide,Nevirapine

Product Name: 3-PyridineCarboxamide,Nevirapine
CAS No.: 133627-47-1
Chemical Name: 3-PyridineCarboxamide,Nevirapine
Synonyms: Naproxen Impurity 49;Nevirapine Impurity 1;3-PyridineCarboxamide,Nevirapine;N-(2-chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)pyridine-3-carboxamide;N-(2-Chioro-4-Methyi-3-Pyndinyl)-2-(Cyclopropyi AMino)-3-Pyridine CarboxaMide;N-(2-Lhioro-4-Methyi-J-Pyndinyl)-2-(Cyclopropyi Amino)-3-Pyridine Carboxamide;3-Pyridinecarboxamide, N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-
CBNumber: CB41029082
Molecular Formula: C15H15ClN4O
Formula Weight: 302.76
MOL File: 133627-47-1.mol

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3-PyridineCarboxamide,Nevirapine Property

Melting point:: 127-129 °C
Boiling point:: 428.9±45.0 °C(Predicted)
Density: 1.429±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 11.17±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 097268
Product name: N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

AK Scientific

Product number: 6105AA
Product name: N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide
Packaging: 250mg
Price: $305
Updated: 2021/12/16

Matrix Scientific

Product number: 097268
Product name: N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide
Purity: 95+%
Packaging: 1g
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036527
Product name: N-(2-CHLORO-4-METHYL-3-PYRIDYL)-2-CYCLOPROPYLAMINO-3-PYRIDINECARBOXAMIDE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036527
Product name: N-(2-CHLORO-4-METHYL-3-PYRIDYL)-2-CYCLOPROPYLAMINO-3-PYRIDINECARBOXAMIDE
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

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3-PyridineCarboxamide,Nevirapine Chemical Properties,Usage,Production

Uses

N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide (CAS# 133627-47-1) is a synthetic intermediate and an impurity of nevirapine (N391275).

Synthesis

133627-45-9

765-30-0

133627-47-1

Example 7: Synthesis of N-(2-chloro-4-methyl-3-pyridinyl)-2-cyclopropylamino-3-pyridinecarboxamide (VII) In an autoclave, 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide (III; 1.0 kg, 3.5587 mol) was dissolved in toluene (6.0 liters). Cyclopropylamine (0.813 kg, 14.23 mol) was then added and the reaction mixture was heated at 125 °C to 130 °C and 15 psi pressure for 21 hours. After completion of the reaction, the mixture was cooled to 25 °C to 30 °C and washed with distilled water. After separating the aqueous layer, the aqueous layer was extracted with ethyl acetate (2.0 liters). The organic layers (toluene and ethyl acetate layers) were combined and concentrated under reduced pressure to give the target product. Yield: 0.857 kg, yield: 79.64%, HPLC purity: 98.14%.

References

[1] Patent: WO2007/10352, 2007, A1. Location in patent: Page/Page column 20

3-PyridineCarboxamide,Nevirapine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-PyridineCarboxamide,Nevirapine Suppliers

China 18 Europe 2 India 3 United States 3 Global 26

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View Lastest Price from 3-PyridineCarboxamide,Nevirapine manufacturers

Career Henan Chemical Co

Product: N-(2-chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)pyridine-3-carboxamide 133627-47-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ＞98%
Supply Ability: 20 tons
Release date: 2020-02-10

133627-47-1, 3-PyridineCarboxamide,NevirapineRelated Search:

Nevirapine

3-PyridineCarboxamide,Nevirapine

N-(2-Lhioro-4-Methyi-J-Pyndinyl)-2-(Cyclopropyi Amino)-3-Pyridine Carboxamide

N-(2-chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)pyridine-3-carboxamide

N-(2-Chioro-4-Methyi-3-Pyndinyl)-2-(Cyclopropyi AMino)-3-Pyridine CarboxaMide

Nevirapine Impurity 1

3-Pyridinecarboxamide, N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-

Naproxen Impurity 49

133627-47-1