Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI)
- Product Name
- Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI)
- CAS No.
- 762263-66-1
- Chemical Name
- Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI)
- Synonyms
- 4-Hydroxy-3-methylbenzeneboronic acid;Boronic acid, (4-hydroxy-3-methylphenyl)-;Boronic acid, B-(4-hydroxy-3-methylphenyl)-;Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI)
- CBNumber
- CB41061932
- Molecular Formula
- C7H9BO3
- Formula Weight
- 151.96
- MOL File
- 762263-66-1.mol
Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI) Property
- Boiling point:
- 358.0±52.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 9.14±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H972503
- Product name
- 4-Hydroxy-3-methylbenzeneboronicacid
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- H972503
- Product name
- 4-Hydroxy-3-methylbenzeneboronicacid
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0061270
- Product name
- (4-Hydroxy-3-methylphenyl)boronicacid
- Purity
- 98.13%
- Packaging
- 100mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- CS-0061270
- Product name
- (4-Hydroxy-3-methylphenyl)boronicacid
- Purity
- 98.13%
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- X0988
- Product name
- 4-Hydroxy-3-methylbenzeneboronicacid
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI) Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
627906-52-9
762263-66-1
General procedure for the synthesis of 4-hydroxy-3-methylphenylboronic acid from 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol: 1. sodium periodate (4.22 g, 19.74 mmol) and ammonium acetate (1.52 g, 19.74 mmol) were added to a mixed solution of acetone and water (2:1, 66 mL) of 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (1.54 g, 6.58 mmol) at room temperature. 2. The reaction mixture was stirred for 19 hours, followed by filtration and concentration. 3. Sodium chloride was added to the concentrated filtrate and extracted with ethyl acetate. 4. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. 5. the residue was purified by silica gel chromatography with gradual transition of the eluent from 1:1 ethyl acetate:hexane to pure ethyl acetate to afford 364.4 mg (36% yield) of 4-hydroxy-3-methylphenylboronic acid as a solid. Product Characterization: 1H NMR (400 MHz, d6-DMSO): δ 9.31 (s, 1H), 7.55 (s, 1H), 7.52 (d, J = 8 Hz, 1H), 6.76 (d, J = 8 Hz, 1H), 2.14 (s, 3H). ESI-LCMS m/z 151 (M-H)-.
References
[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 80
Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI) manufacturers
- Product
- Boronic acid, (4-hydroxy-3-methylphenyl)- (9CI) 762263-66-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03