Pyrimidine, 2,4-dibromo-5-methyl- (9CI)
- Product Name
- Pyrimidine, 2,4-dibromo-5-methyl- (9CI)
- CAS No.
- 494194-61-5
- Chemical Name
- Pyrimidine, 2,4-dibromo-5-methyl- (9CI)
- Synonyms
- 2,4-dibromo-5-methylpyrimidine;Pyrimidine, 2,4-dibromo-5-methyl-;Pyrimidine, 2,4-dibromo-5-methyl- (9CI)
- CBNumber
- CB41065804
- Molecular Formula
- C5H4Br2N2
- Formula Weight
- 251.91
- MOL File
- 494194-61-5.mol
Pyrimidine, 2,4-dibromo-5-methyl- (9CI) Property
- Boiling point:
- 327.0±34.0 °C(Predicted)
- Density
- 2.022±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.78±0.29(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A195401
- Product name
- 2,4-Dibromo-5-methylpyrimidine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- A195401
- Product name
- 2,4-Dibromo-5-methylpyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- A195401
- Product name
- 2,4-Dibromo-5-methylpyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- CM253177
- Product name
- 2,4-Dibromo-5-methylpyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- A195401
- Product name
- 2,4-Dibromo-5-methylpyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $229
- Updated
- 2021/12/16
Pyrimidine, 2,4-dibromo-5-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
65-71-4
494194-61-5
General procedure for the synthesis of 2,4-dibromo-5-methylpyrimidine from 5-methyluracil: Thymine (3.7 g, 29 mmol) and phosphorus pentoxide (25.0 g, 87.2 mmol) were dissolved in acetonitrile (150 mL) at 0 °C, followed by batchwise addition of potassium carbonate (12.1 g, 87.2 mmol). The reaction mixture was gradually warmed to room temperature, then heated to 80 °C and maintained for 3 days. Upon completion of the reaction, the mixture was poured into ice water and the pH was adjusted with solid potassium carbonate to 7. The aqueous layer was extracted with dichloromethane and the organic layer was sequentially washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: 0-30% ethyl acetate/hexane) afforded the target product 2,4-dibromo-5-methylpyrimidine (7.1 g, 96% yield) as a white solid. lC-MS (ES) m/z = 251, 253 and 255 [M + H]+ .
References
[1] Patent: WO2008/147831, 2008, A1. Location in patent: Page/Page column 15
[2] Organic Letters, 2002, vol. 4, # 26, p. 4697 - 4699
Pyrimidine, 2,4-dibromo-5-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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