Fendosal
- Product Name
- Fendosal
- CAS No.
- 53597-27-6
- Chemical Name
- Fendosal
- Synonyms
- hp129;CS-86;alnovin;FENDOSAL;Fendozal;P 71-0129;5-(4,5-dihydro-2-phenyl-3h-benz[e]indol-3-yl)salicylic acid;2-hydroxy-5-{2-phenyl-3H,4H,5H-benzo[e]indol-3-yl}benzoic acid;3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole;5-(4,5-dihydro-2-phenyl-3h-benz(e)indol-3-yl)-2-hydroxybenzoicacid
- CBNumber
- CB4107778
- Molecular Formula
- C25H19NO3
- Formula Weight
- 381.42
- MOL File
- 53597-27-6.mol
Fendosal Property
- Melting point:
- 223-225° (dec)
- Boiling point:
- 508.82°C (rough estimate)
- Density
- 1.2182 (rough estimate)
- refractive index
- 1.6000 (estimate)
- pka
- 2.40±0.10(Predicted)
- CAS DataBase Reference
- 53597-27-6(CAS DataBase Reference)
Safety
- Toxicity
- LD50 in mice, rats, rabbits (mg/kg): 740, 450, 560 orally; in mice (mg/kg): 510 i.p. (Lassman)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0010526
- Product name
- 2-HYDROXY-5-(2-PHENYL-4,5-DIHYDRO-BENZO[E]INDOL-3-YL)-BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.03
- Updated
- 2021/12/16
- Product number
- P028
- Product name
- Fendosal
- Packaging
- 250mg
- Price
- $677
- Updated
- 2021/12/16
- Product number
- 090375
- Product name
- 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-salicylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- 090375
- Product name
- 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-salicylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1425
- Updated
- 2021/12/16
- Product number
- API0010526
- Product name
- 2-HYDROXY-5-(2-PHENYL-4,5-DIHYDRO-BENZO[E]INDOL-3-YL)-BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575
- Updated
- 2021/12/16
Fendosal Chemical Properties,Usage,Production
Originator
Alnovin,Hoechst
Uses
Anti-inflammatory.
Definition
ChEBI: Fendosal is a benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity. It has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a member of pyrroles, a benzoindole and a monohydroxybenzoic acid.
Manufacturing Process
To a stirred refluxing solution of 20.2 g (0.1 mole) of 1-(1-pyrrolidino)-3,4-
dihydronaphthalene and 50 ml of toluene was added dropwise during 30 minutes under nitrogen a solution of 20.1 g (0.1 mole) of phenacyl bromide in
65 ml of dry toluene. The mixture was heated under reflux for 6 hours, diluted
with 50 ml of water, refluxed for 4 hours, and cooled. The layers were
separated and the aqueous phase was extracted with benzene. The organic
solution was dried over sodium sulfate and concentrated to a semi-solid.
Trituration with cold 30°-60° petroleum ether gave 23.6 g (78%) of solid, 2-
phenacyl-1-tetralone, MP: 73°-76°C. Recrystallization from 60°-90° petroleum
ether raised the melting point to 87°-88°C.
A mixture of 20.0 g (0.076 mole) of 2-phenacyl-1-tetralone, 11.6 g (0.076
mole) of 5-aminosalicyclic acid, and 70 ml of glacial acetic acid was heated
under reflux for 4 hours, cooled, diluted with 10 ml of water and filtered. The
filter cake was washed with water and dried to provide 15.5 g of solid, 5-(4,5-
dihydro-2-phenyl-3H-benz[e]indol-3-yl)-2-hydroxy-benzoic acid. MP: 215°-
218°C. Recristallization from benzene-cyclohexane gave 6.5 g (22%) of yellow
crystals, MP: 245°-247°C.
brand name
Alnovin(Hoechst-Roussel).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Fendosal Preparation Products And Raw materials
Raw materials
Preparation Products
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